The Potential of Streptococcus agalactiae as an Antimicrobial-Resistant in Aquaculture Under Global Warming

DOI

10.2991/978-94-6463-942-1_5How to use a DOI?

Keywords

Aquatic Environment; Pathogenicity; Sequence Type; Virulence Gene; Temperature Shift

Abstract

Fish living in aquatic ecosystems constantly encounter spatial and temporal changes in water temperature that shape their physiology and survival. Such thermal variation also modulates the immune response of fish against bacterial infection. Temperature shifts influence bacterial morphology, metabolism, and pathogenicity, leading to increased fish mortalities from GBS infections—an outcome rarely observed at water temperatures below 25℃. The research objective is to conduct molecular detection of zoonotic diseases and antimicrobial resistance in fish and their relationship to humans and the environment. Molecular analyses included Multi-Locus Sequence Typing (MLST) based on seven gene loci and genome-based prediction of antimicrobial resistance (AMR) profiles. Serotypes Ia, Ib, and III were detected in isolates originating from both fish and humans. Sequence type (ST) assignment was based on variation in seven housekeeping genes—adhP, pheS, atr, glnA, sdhA, glcK, and tkt. MLST revealed that S. agalactiae shifted from ST 261 to ST 283 following exposure to high-temperature conditions. Elevated temperature did not alter its antimicrobial resistance profile. A panel of virulence genes —including acpC, cylA, cylB, cylD, cylF, cylI, cylX, cylZ, cfa, cfb, cpsB, cpsC, scpB, neuB, neuD, and cylG—were expressed by S. agalactiae following exposure to high temperatures. This temperature-dependent expression highlights S. agalactiae’s dynamic nature and reinforces its potential as a zoonotic threat in tilapia aquaculture under global warming conditions.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - A. M. Lusiastuti
AU  - S. Senapin
AU  - T. D. Hoai
AU  - D. Safari
AU  - Y. Maladan
AU  - H. Novita
AU  - T. Penataseputro
AU  - A. W. M. Putri
AU  - D. Sugiani
AU  - D. Syahidah
AU  - P. P. Nugroho
AU  - U. Purwaningsih
AU  - T. Sumiati
AU  - K. Nisaa
AU  - S. Suryanto
AU  - B. Pantjara
AU  - T. H. Prihadi
PY  - 2025
DA  - 2025/12/29
TI  - The Potential of Streptococcus agalactiae as an Antimicrobial-Resistant in Aquaculture Under Global Warming
BT  - Proceedings of the 3rd International Seminar on Fish and Fisheries Sciences (ISFFS 2025)
PB  - Atlantis Press
SP  - 42
EP  - 51
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-942-1_5
DO  - 10.2991/978-94-6463-942-1_5
ID  - Lusiastuti2025
ER  -