The Preventive Effect of Virgin Coconut Oil (VCO) with Lime Acidification (Citrus aurantifolia) on Total Cholesterol Levels and Expression of Hepatic TGF-β on Hypercholesterolemic Rats (Rattus norvegicus)

DOI

10.2991/absr.k.220309.098How to use a DOI?

Keywords

Hypercholesterolemia; Total cholesterol; Hepatic TGF-β; VCO with lime acidification

Abstract

Hypercholesterolemia is an excessive level of blood cholesterol condition. Fat and high cholesterol overconsumption cause atherosclerosis, coronary heart diseases, and liver diseases e.g. fatty liver and non-alcoholic steatohepatitis (NASH). One ingredient that can be used to prevent hypercholesterolemia is Virgin Coconut Oil (VCO) with lime acidification. This acidification is to increase lauric acid in VCO. The objective of this study is to determine the prevention effect of Virgin Coconut Oil (VCO) with lime acidification on the increase of serum total cholesterol levels, and the expression of hepatic TGF-β. The study was conducted with an experimental method using a complete randomized design on 20 white rats Rattus norvegicus) male Wistar strain aged 10-12 weeks and weight 200-250 grams as samples. Samples were divided into five treatment groups with four replications for each group, namely K- (negative control), K+ (positive control with hyper cholesterol feeding without VCO), P1 (1 ml VCO + 3.02 g hyper cholesterol feeding), P2 (1.5 ml VCO + 3.02 g hyper cholesterol feeding), and P3 (2 ml VCO + 3.02 g hyper cholesterol feeding). Data analysis of serum total cholesterol levels and the expression of hepatic TGF-β was performed by One Way Analysis of Variance (ANOVA) (α = 0.05). The results showed that administration of VCO with lime acidification (Citrus aurantifolia) using three different dosages could prevent the increasing total cholesterol levels, but had not been proven to have a preventive effect on the increasing hepatic TGF-β expression on hypercholesterolemia white rats.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Indah Amalia Amri
AU  - Falyudhanto Aryo Wibisono
AU  - Aulia Firmawati
AU  - Nurina Titisari
AU  - Dahliatul Qosimah
PY  - 2022
DA  - 2022/03/29
TI  - The Preventive Effect of Virgin Coconut Oil (VCO) with Lime Acidification (Citrus aurantifolia) on Total Cholesterol Levels and Expression of Hepatic TGF-β on Hypercholesterolemic Rats (Rattus norvegicus)
BT  - Proceedings of the International Conference on Improving Tropical Animal Production for Food Security (ITAPS 2021)
PB  - Atlantis Press
SP  - 511
EP  - 516
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220309.098
DO  - 10.2991/absr.k.220309.098
ID  - Amri2022
ER  -