Rs10830963 Polymorphism of the MTNR1B Gene in Type 2 Diabetes Mellitus Patients with Dyslipidemia and Non-Dyslipidemia

DOI

10.2991/978-94-6463-132-6_17How to use a DOI?

Keywords

Polymorphism; rs10830963 MTNR1B of Type 2 Diabetes Mellitus; Dyslipidemia

Abstract

Background: Insulin resistance in Diabetes mellitus is found to be the contributor to atherogenic dyslipidemia and results in diabetic dyslipidemia. Rs10830963 polymorphism of the MTNR1B gene is proven to be significant for obesity in T2DM which is usually accompanied by lipid metabolism disorder.

Aim: This research aims to identify the correlation between rs10830963 polymorphism of the MTNR1B gene with the risk of dyslipidemia in Javanese T2DM patients.

Methods: This study used cross-sectional study which involved 107 patients with T2DM treatment at some primary health care centre in Semarang. Gene polymorphism was analyzed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The polymorphism of rs10830963 MTNR1B was presented in allele frequency and genotype frequency, then analyzed using the x² test with p < 0.05.

Results: Most of the respondents were found to have a C allele in both groups. On the other hand, the CG genotype was the most found in both groups. There was no significant difference between groups in terms of allele frequency (p = 0.767) and genotype frequency (p = 0.507). The significant difference was only found in the microalbuminuria parameter of the dyslipidemia group (p = 0.028) and BMI of the non-dyslipidemia group (p = 0.018).

Conclusion: The polymorphism rs10830963 MTNR1B does not play a role in the risk of dyslipidemia in Javanese T2DM patients. Meanwhile, there is significant difference in the microalbuminuria parameter of the dyslipidemia group and BMI of the non-dyslipidemia group.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Yanuarita Tursinawati
AU  - Ari Yuniastuti
PY  - 2023
DA  - 2023/04/19
TI  - Rs10830963 Polymorphism of the MTNR1B Gene in Type 2 Diabetes Mellitus Patients with Dyslipidemia and Non-Dyslipidemia
BT  - Proceedings of the 1st Lawang Sewu International Symposium 2022 on Health Sciences (LSISHS 2022)
PB  - Atlantis Press
SP  - 138
EP  - 145
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-132-6_17
DO  - 10.2991/978-94-6463-132-6_17
ID  - Tursinawati2023
ER  -