Proceedings of the 2014 International Conference on Mechatronics, Electronic, Industrial and Control Engineering

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Bioinformatics Study on Relationship of Hyperlipidemia and Phospholipids Based on Cytoscape Software

Authors
Zhongfeng Shi, Yifan Feng, Wen Rui, Jiao Guo
Corresponding Author
Zhongfeng Shi
Available Online November 2014.
DOI
10.2991/meic-14.2014.80How to use a DOI?
Keywords
Bioinformatics study; Hyperlipidemia; Phospholipids; Cytoscape; ClusterONE
Abstract

Objective Phospholipids are one of important factors in Hyperlipidemia development. To discover relationship of Hyperlipidemia and phospholipids, we carried out this study. Methods: We carried on the bioinformatics study on the relationship by Cytoscape software with Agilent Literature Search and ClusterONE plugins loaded. To search literatures of the relationship by Agilent Literature Search plugin and the network was generated and laid out in a new window. Loaded the above network into Cytoscape and new networks were generated by cluster analysis. Results: The network generated through Agilent Literature Search plugin includes 72 nodes and 95 edges. 14 clusters were generated by ClusterONE after cluster analysis, in which there are 7 clusters (p-value less than 0.05) were statistically significant, the node size is 3-7. The 7 predominant network pathway which could explain the relationship of Hyperlipidemia and phospholipids. Conclusion :The Cytoscape software with Agilent Literature Search and ClusterONE plugins is very powerful tool for discover potential pathways to explain Pathophysiology mechanism.

Copyright
© 2014, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2014 International Conference on Mechatronics, Electronic, Industrial and Control Engineering
Series
Advances in Engineering Research
Publication Date
November 2014
ISBN
10.2991/meic-14.2014.80
ISSN
2352-5401
DOI
10.2991/meic-14.2014.80How to use a DOI?
Copyright
© 2014, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Zhongfeng Shi
AU  - Yifan Feng
AU  - Wen Rui
AU  - Jiao Guo
PY  - 2014/11
DA  - 2014/11
TI  - Bioinformatics Study on Relationship of Hyperlipidemia and Phospholipids Based on Cytoscape Software
BT  - Proceedings of the 2014 International Conference on Mechatronics, Electronic, Industrial and Control Engineering
PB  - Atlantis Press
SP  - 357
EP  - 360
SN  - 2352-5401
UR  - https://doi.org/10.2991/meic-14.2014.80
DO  - 10.2991/meic-14.2014.80
ID  - Shi2014/11
ER  -