Proceedings of the 2015 International Conference on Mechatronics, Electronic, Industrial and Control Engineering

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The Impact of the Uighur Medicine Seeds of Nigella Glandulifera Freyn (SNF) on Antitumor and Antioxidant Activity in a S180 and EAC Mouse Tumor Model

Authors
Dilinuer Maimaitiyiming, Amanguli, Li Yan, Nazuk Kurbantay, Guizhen Wu, Lianlian Shan, Zuhragul Omarniyaz, Tao Yang, Shuge Tian, Halmurat Upur, Ainiwaer Aikemu
Corresponding Author
Dilinuer Maimaitiyiming
Available Online April 2015.
DOI
10.2991/meic-15.2015.232How to use a DOI?
Keywords
Uighur medicine; Seeds of Nigella Glandulifera Freyn; antioxidant; antitumor; antihypoxia
Abstract

Objective: This study was designed to study the antitumor, antioxidant activity and antihypoxia of Uighur medicine Seeds of Nigella glandulifera Freyn (SNF) in the S180 and EAC mice tumor model. Methods: A total of 100 were randomly divided into five groups with 20 animals in each group: control group, model group, Seeds of Nigella glandulifera Freyn ethanol extract (SNFEE) group, Seeds of Nigella glandulifera Freyn water extract (SNFWE) group, cyclophosphamide group. The serum levels of superoxide dismutase (SOD), malonaldehyde (MDA), and glutathione-catalase (GSH-PX) were analyzed, and the mice were also subjected to a hypoxia tolerance test. Their climbing ability was also analyzed. Results: The findings of the study revealed that SNF-treatment leads to an increase in blood serum SOD and GSH-PX levels but a decrease in blood serum MDA levels. Moreover, SNF-treatment enhanced the survival time of mice maintained under hypoxic conditions and improved their mice climbing ability. Conclusion: The results of this study indicate that SNF has obvious antitumor, antihypoxia and antioxidative effects.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 International Conference on Mechatronics, Electronic, Industrial and Control Engineering
Series
Advances in Engineering Research
Publication Date
April 2015
ISBN
10.2991/meic-15.2015.232
ISSN
2352-5401
DOI
10.2991/meic-15.2015.232How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Dilinuer Maimaitiyiming
AU  - Amanguli
AU  - Li Yan
AU  - Nazuk Kurbantay
AU  - Guizhen Wu
AU  - Lianlian Shan
AU  - Zuhragul Omarniyaz
AU  - Tao Yang
AU  - Shuge Tian
AU  - Halmurat Upur
AU  - Ainiwaer Aikemu
PY  - 2015/04
DA  - 2015/04
TI  - The Impact of the Uighur Medicine Seeds of Nigella Glandulifera Freyn (SNF) on Antitumor and Antioxidant Activity in a S180 and EAC Mouse Tumor Model
BT  - Proceedings of the 2015 International Conference on Mechatronics, Electronic, Industrial and Control Engineering
PB  - Atlantis Press
SP  - 1017
EP  - 1023
SN  - 2352-5401
UR  - https://doi.org/10.2991/meic-15.2015.232
DO  - 10.2991/meic-15.2015.232
ID  - Maimaitiyiming2015/04
ER  -