Proceedings of the 2021 6th International Conference on Modern Management and Education Technology(MMET 2021)

Sex Hormone and Sex Hormone Receptors Modulation of Exercise-induced Neurogenesis

Authors
Peiyi Liu
Corresponding Author
Peiyi Liu
Available Online 12 October 2021.
DOI
https://doi.org/10.2991/assehr.k.211011.099How to use a DOI?
Keywords
exercise-induced neurogenesis, sex hormones, sex hormone receptors, depression-like behavior
Abstract

Adult hippocampal neurogenesis (AHN) has been widely studied in many aspects. AHN is showed to have causal relationship with depression and anxiety. Experimental data showed that sex hormones and sex hormone receptors can be a factor that modulates AHN. However, few studies have focused on sex hormones’ effect on exercise-induced neurogenesis, which the detailed mechanism is unknown to people. In this paper, we designed the experiments to find a casual relationship between sex hormones (receptors) and exercise-induced neurogenesis. We utilized castration (TX) and ovariectomy (OVX) to control the hormone level within the rats’ body. Noteworthy, we also tested how can the numerical ratios of androgen to estrogen and androgen receptors to estrogen receptors affect exercise-induced neurogenesis by using conditional gene knockout and Cre recombinase. If the results turn out to be consistent with the hypothesis that the level of sex hormones and sex hormone receptors have influences on exercise-induced neurogenesis and depression-like behavior, we can put forward a treatment on anxiety disorders concerning the combination of exercise and sex hormone regulation.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2021 6th International Conference on Modern Management and Education Technology(MMET 2021)
Series
Advances in Social Science, Education and Humanities Research
Publication Date
12 October 2021
ISBN
10.2991/assehr.k.211011.099
ISSN
2352-5398
DOI
https://doi.org/10.2991/assehr.k.211011.099How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Peiyi Liu
PY  - 2021
DA  - 2021/10/12
TI  - Sex Hormone and Sex Hormone Receptors Modulation of Exercise-induced Neurogenesis
BT  - Proceedings of the 2021 6th International Conference on Modern Management and Education Technology(MMET 2021)
PB  - Atlantis Press
SP  - 543
EP  - 548
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.211011.099
DO  - https://doi.org/10.2991/assehr.k.211011.099
ID  - Liu2021
ER  -