Advantages and Challenges of Roller Compaction Process for Dry Granulation
- DOI
- 10.2991/assehr.k.220701.048How to use a DOI?
- Keywords
- Roller compaction; advantages and challenges; dry granulation
- Abstract
Granulation, which is a technology of expanding particles by coagulation, is one of the most significant unit operations for the production of drug dosage forms (mainly capsules and tablets). In the granulation process, fine or coarse particles are transformed into large aggregates called particles. Granulation processes can be divided into two types: wet granulation and dry granulation (also called RC). The difference between the two processes is whether utilize liquid. Granulation has many advantages and has made considerable success, especially for dry granulation. However, because the formed particles have high-quality requirements in terms of content uniformity, physicochemical properties and stability of drugs, which bring dry granulation many challenges. Among currently available technologies, dry granulation can be achieved by rolling or slug granulation. This review focuses on the roller compaction process for dry granulation. This review summarizes the development, significance, and limitations of the roller compaction process for dry granulation. This review focuses on the roller compaction process for dry granulation. Through the retrieval and reading of relevant literature, this paper puts forward the advantages and challenges of the roller compaction process for dry granulation.
- Copyright
- © 2022 The Authors. Published by Atlantis Press SARL.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license.
Cite this article
TY - CONF AU - Feiyang Wu PY - 2022 DA - 2022/07/04 TI - Advantages and Challenges of Roller Compaction Process for Dry Granulation BT - Proceedings of the 2022 International Conference on Science and Technology Ethics and Human Future (STEHF 2022) PB - Atlantis Press SP - 236 EP - 239 SN - 2352-5398 UR - https://doi.org/10.2991/assehr.k.220701.048 DO - 10.2991/assehr.k.220701.048 ID - Wu2022 ER -