Proceedings of the Turakulov Readings 2025 Conference (TR 2025)

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The Role of Inactive Pituitary Adenoma in the Development of Hypogonadotropic Hypogonadism

Authors
Hamrayeva Dilafruz Ismatullo Qizi1, *, Kholova Dilorom Sharifovna1, Badridinova Barnokhon Kamalidinovna2, Yaxyoyeva Xilola Sharifovna2, Rizayeva Mekhriban Akhmadovna2
1The Republican Specialized Scientific and Practical Medical Center of Endocrinology named after. acad. Y. X. Turakulov, Turakulov, Uzbekistan
2Department of Endocrinology Bukhara State Medical Institute named after Abu Ali Ibn Sina, Turakulov, Uzbekistan
*Corresponding author. Email: dilafruzhamrayeva@gmail.com
Corresponding Author
Hamrayeva Dilafruz Ismatullo Qizi
Available Online 26 December 2025.
DOI
10.2991/978-94-6463-984-1_9How to use a DOI?
Keywords
Hypogonadotropic hypogonadism; pituitary adenoma; chiasmatic-sellar region tumors; amenorrhea; infertility; neurovegetative disorders
Abstract

This article explores the impact of inactive pituitary adenoma on the development of hypogonadotropic hypogonadism in women. A clinical study was conducted on 76 female patients aged 18 to 47 years to assess hormonal changes and clinical manifestations. The study found that hypogonadotropic hypogonadism is the most frequent clinical indication of pituitary insufficiency (67%) in tumors of the chiasmatic-sellar region. Key symptoms include menstrual irregularities, infertility, neurovegetative and urogenital disorders, and underdevelopment of the uterus and ovaries. The symptoms of hypogonadism typically emerge in the early stages of the disease, preceding the onset of visual and neurological impairments. The diagnosis is confirmed by reduced levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
Series
Advances in Health Sciences Research
Publication Date
26 December 2025
ISBN
978-94-6463-984-1
ISSN
2468-5739
DOI
10.2991/978-94-6463-984-1_9How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Hamrayeva Dilafruz Ismatullo Qizi
AU  - Kholova Dilorom Sharifovna
AU  - Badridinova Barnokhon Kamalidinovna
AU  - Yaxyoyeva Xilola Sharifovna
AU  - Rizayeva Mekhriban Akhmadovna
PY  - 2025
DA  - 2025/12/26
TI  - The Role of Inactive Pituitary Adenoma in the Development of Hypogonadotropic Hypogonadism
BT  - Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
PB  - Atlantis Press
SP  - 85
EP  - 91
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-984-1_9
DO  - 10.2991/978-94-6463-984-1_9
ID  - Qizi2025
ER  -