Proceedings of the Turakulov Readings 2025 Conference (TR 2025)

<Previous Article In Volume
Next Article In Volume>

Clinical - Hormonal, Imaging and Immune - Histochemical Features of Inactive Pituitary Adenomas with Recurrent and Stable Course

Authors
Kholova Dilorom Sharifovna1, Hamrayeva Dilafruz Ismatullo Qizi1, *, Khikmatullaeva Rakshona Alisherovna1, Razakova Shokhsanam Tulkinovna2, Khasanova Gulhayo Sayphiddin Qizi3
1Republican Specialized Scientific and Practical Medical Center of Endocrinology named after. acad. Y. X. Turakulov, Turakulov, Uzbekistan
2Department of Hospital Therapy and Endocrinology, Andijan State Medical Institute, Andijan, Uzbekistan
3Department of Clinical Sciences, Faculty of Medicine, Gulistan State University, Mirzachul, Uzbekistan
*Corresponding author. Email: dilafruzhamrayeva@gmail.com
Corresponding Author
Hamrayeva Dilafruz Ismatullo Qizi
Available Online 26 December 2025.
DOI
10.2991/978-94-6463-984-1_10How to use a DOI?
Keywords
Inactive pituitary adenomas; Relapsing course; Stable flow; Transcription factors; Diagnostics
Abstract

Inactive pituitary adenoma (IPA) or “Silent Pituitary Adenomas” refers to tumors that secrete one or more hormones or their transcription factors (TFs), detected by immunohistochemistry (IHC), but the amount of hormones expressed is not has clinical significance and is not expressed by symptom complexes [2]. This research aims to analyze in a comparative aspect the clinical, hormonal, imaging and IHC features of inactive pituitary adenomas with a recurrent and stable course. In total, the data of 100 patients with IPA were analyzed: group 1 included 50 patients with a recurrent course, group 2 included 50 patients with a stable course. The result shows both groups were predominantly men under 45 years of age. In the group with a recurrent course, nausea (46% vs. 4.0%; OR 9.80; 95% CI 3.06-31.4; p < 0.0001) and dizziness (46.0% vs. 20.0%; OR 3.41; 95% CI 1.40-8.29; p = 0.006) were significantly more common than in the group with a stable course. Along with this, in the group with a recurrent course of the disease, endocrine (100% versus 92.0%) and general somatic (100% versus 76.0%) disorders predominated. A comparative analysis showed that significant factors in the epigenetic modification of the risk of relapse are stress (OR 17.5; 95% CI 6.31-48.4; p < 0.0001), brain injury (OR 3.02; 95% CI 1 .27-7.21; p = 0.01), obesity (OR 4.89; 95% CI 1.76-13.6; p = 0.002) and emotional stress (OR 2.79; 95% CI 1, 11-7.01; p = 0.03).

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

<Previous Article In Volume
Next Article In Volume>
Volume Title
Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
Series
Advances in Health Sciences Research
Publication Date
26 December 2025
ISBN
978-94-6463-984-1
ISSN
2468-5739
DOI
10.2991/978-94-6463-984-1_10How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Kholova Dilorom Sharifovna
AU  - Hamrayeva Dilafruz Ismatullo Qizi
AU  - Khikmatullaeva Rakshona Alisherovna
AU  - Razakova Shokhsanam Tulkinovna
AU  - Khasanova Gulhayo Sayphiddin Qizi
PY  - 2025
DA  - 2025/12/26
TI  - Clinical - Hormonal, Imaging and Immune - Histochemical Features of Inactive Pituitary Adenomas with Recurrent and Stable Course
BT  - Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
PB  - Atlantis Press
SP  - 92
EP  - 102
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-984-1_10
DO  - 10.2991/978-94-6463-984-1_10
ID  - Sharifovna2025
ER  -