Artery Research

Volume 26, Issue 1, March 2020, Pages 13 - 20

Aortic Stiffness in HIV Infection with and without Antiretroviral Therapy. A Meta-analysis of Observational Studies

Authors
Giovanni Mulè1, , Giuseppe Mulè2, *, , Valeria Tranchida2, Pietro Colletti1, Giovanni Mazzola1, Marcello Trizzino1, Claudia Colomba1, Antonio Cascio1
1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Unit of Infectious Diseases, University of Palermo, via del Vespro, 129, Palermo 90127, Italy
2European Society of Hypertension Excellence Centre, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Unit of Nephrology and Hypertension, University of Palermo, via del Vespro, 129, Palermo 90127, Italy

These two authors contributed equally to this work.

*Corresponding author. Email: giuseppe.mule@unipa.it
Corresponding Author
Giuseppe Mulè
Received 12 March 2020, Accepted 14 March 2020, Available Online 19 March 2020.
DOI
https://doi.org/10.2991/artres.k.200314.002How to use a DOI?
Keywords
HIV infection; cardiovascular risk; pulse wave velocity; aortic stiffness
Abstract

Background: The risk of Cardiovascular (CV) events is higher in HIV-infected patients (HIV+) compared to HIV-uninfected persons (HIV−). Large artery stiffness, a well-documented predictor of adverse CV prognosis, may mediate this enhanced risk. It is usually assessed by measuring aortic Pulse Wave Velocity (aPWV). Studies examining arterial stiffness in HIV+ yielded inconsistent results. We performed a meta-analysis with the aim to evaluate the association of HIV infection and its therapy [Antiretroviral Therapy (ART)] with aPWV.

Design and Method: The Standardized Mean Difference (SMD) and corresponding 95% confidence intervals were calculated for aPWV in different comparison groups. Statistical heterogeneity, assessed by Q-test and I2 statistic, was observed in all these comparisons. Therefore, random effects model was implemented.

Results: In a total of 12 studies, naive HIV+ (n = 547) showed increased aPWV compared to HIV− (n = 864): SMD = 0.333 (0.125–0.542), p < 0.002. A total of 22 studies were identified comparing HIV+ treated with ART (n = 3348) to HIV− (n = 2547) showing higher values of aPWV in the former than in latter: SMD = 0.391 (0.225–0.556), p < 0.001. In 10 studies, HIV+ treated with ART (n = 761) exhibited greater aPWV values than those of naive HIV+ (n = 457): SMD = 0.262 (0.006–0.518), p = 0.045.

Conclusion: Our meta-analysis seems to suggest that HIV infection “per se” and ART may impair aortic distensibility. However, interpretation of our results needs caution due to between-study heterogeneity and some potential publication biases.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - 1
Pages
13 - 20
Publication Date
2020/03/19
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.2991/artres.k.200314.002How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Giovanni Mulè
AU  - Giuseppe Mulè
AU  - Valeria Tranchida
AU  - Pietro Colletti
AU  - Giovanni Mazzola
AU  - Marcello Trizzino
AU  - Claudia Colomba
AU  - Antonio Cascio
PY  - 2020
DA  - 2020/03/19
TI  - Aortic Stiffness in HIV Infection with and without Antiretroviral Therapy. A Meta-analysis of Observational Studies
JO  - Artery Research
SP  - 13
EP  - 20
VL  - 26
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200314.002
DO  - https://doi.org/10.2991/artres.k.200314.002
ID  - Mulè2020
ER  -