Factors Associated with Cardio Ankle Vascular Index (CAVI) and its Mathematically Corrected Formula (CAVI₀) in Community Dwelling Individuals

Authors

Li-Ju Lin¹, Nan-Chen Hsieh², Shu-Fang Vivienne Wu³, Tan-Hsu Tan^4, , Azadeh Alizargar⁴, Chyi-Huey Bai⁵, Javad Alizargar^{6, *,}

¹Department of Geronological Health Care, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

²Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

³College of Nursing, School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

⁴Department of Electrical Engineering, National Taipei University of Technology, Taipei City 10608, Taiwan

⁵Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan

⁶Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan

^*Corresponding author. Email: jaz.tmu@gmail.com

DOI

10.2991/artres.k.201124.002How to use a DOI?

Keywords

Atherosclerosis; cardiovascular diseases; cardio ankle vascular index; ankle brachial index; hypertension; atherosclerosis; risk factor

Abstract

Cardio Ankle Vascular Index (CAVI) and mathematically corrected formula derived from it (CAVI₀) are indices for arterial stiffness and atherosclerosis. Role of different atherosclerotic risk factors on CAVI and CAVI₀ is not clear in the community dwelling individuals. This study aims to evaluate the association of different Cardiovascular Disease (CVD) risk factors on CAVI and CAVI₀. Participants from a prospective cohort study have been recruited for CAVI measurement. Known risk factors for atherosclerosis were assessed in the individuals. CAVI and CAVI₀ is highly correlated (Pearson’s r = 0.95 and p < 0.001). Further correlation analysis of the study variables with CAVI shows that CAVI is significantly correlated with age, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP). CAVI₀ is also significantly correlated with age, SBP and MBP. CAVI₀ is not correlated with DBP (Pearson’s r = 0.05 and p = 0.46). Among laboratory tests, CAVI and CAVI₀ are correlated with Blood Urea Nitrogen (BUN) (r = 0.20, p = 0.009 and r = 0.22, p = 0.004 respectively) and also with HBA1c (r = 0.21, p = 0.006 and r = 0.25, p = 0.001 respectively). Multivariate analysis showed that only age is independent determinant of CAVI and CAVI₀. As SBP and DBP are not independently associated with CAVI and CAVI₀, these indices could be considered reliable in differentiating people with high risks of CVD, as it is not dependent on other risk factors. As CAVI₀ is not correlated with DBP, when evaluating the results of CAVI₀, we should consider that this index maybe not be reflective of DBP in the patient.

Copyright

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Li-Ju Lin
AU  - Nan-Chen Hsieh
AU  - Shu-Fang Vivienne Wu
AU  - Tan-Hsu Tan
AU  - Azadeh Alizargar
AU  - Chyi-Huey Bai
AU  - Javad Alizargar
PY  - 2020
DA  - 2020/12/08
TI  - Factors Associated with Cardio Ankle Vascular Index (CAVI) and its Mathematically Corrected Formula (CAVI₀) in Community Dwelling Individuals
JO  - Artery Research
SP  - 53
EP  - 58
VL  - 27
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201124.002
DO  - 10.2991/artres.k.201124.002
ID  - Lin2020
ER  -