Combining Resting-state fMRI and DTI Analysis for Early-onset Schizophrenia

DOI

10.2991/ijcis.2009.2.4.6How to use a DOI?

Keywords

Functional connectivity, Anatomical connectivity, Resting fMRI, Fractional anisotropy, Earlyonset schizophrenia

Abstract

We combined measures of resting-state functional magnetic resonance imaging and diffusion tensor imaging (DTI) to investigate alterations of function-structure relationships in patients with early-onset schizophrenia. DTI analysis revealed reduced fractional anisotropy in right frontal white matter. Corresponding gray matter regions showed reduced functional connectivity with other regions in the brain in patients with early-onset schizophrenia, compared with healthy controls. Our results demonstrated abnormal function-structure relationships in early-onset schizophrenia, and supported the view that white matter lesions might disrupt the neural circuits between frontal regions and other brain regions, and affect the functional connectivity in the frontal cortex.

Copyright

© 2009, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Ming Ke
AU  - Hui Shen
AU  - Jintu Fan
AU  - Xing Huang
AU  - Zongtan Zhou
AU  - Xiaogang Chen
AU  - Dewen Hu
PY  - 2009
DA  - 2009/12/01
TI  - Combining Resting-state fMRI and DTI Analysis for Early-onset Schizophrenia
JO  - International Journal of Computational Intelligence Systems
SP  - 375
EP  - 385
VL  - 2
IS  - 4
SN  - 1875-6883
UR  - https://doi.org/10.2991/ijcis.2009.2.4.6
DO  - 10.2991/ijcis.2009.2.4.6
ID  - Ke2009
ER  -