Factors associated with breast cancer in Puerto Rican women

Luisa Morales; Carolina Alvarez-Garriga; Jaime Matta; Carmen Ortiz; Yeidyly Vergne; Wanda Vargas; Heidi Acosta; Jonathan Ramírez; Julyann Perez-Mayoral; Manuel Bayona

doi:10.1016/j.jegh.2013.08.003

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Volume 3, Issue 4, December 2013, Pages 205 - 215

Factors associated with breast cancer in Puerto Rican women

Authors

Luisa Morales^a^{, b}^{, *}^,lmorales@psm.edu, Carolina Alvarez-Garriga^b, Jaime Matta^a, Carmen Ortiz^a, Yeidyly Vergne^b, Wanda Vargas^a, Heidi Acosta^b, Jonathan Ramírez^a, Julyann Perez-Mayoral^a, Manuel Bayona^b

^aDepartment of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, P.O. Box 7004-388, Ponce 00732-7004, Puerto Rico

^bPublic Health Program, Ponce School of Medicine and Health Sciences, P.O. Box 7004-388, Ponce 00732-7004, Puerto Rico

^*Corresponding author at: Department of Physiology and Pharmacology, Ponce School of Medicine and Health Sciences, P.O. Box 7004-388, Ponce 00732-7004, Puerto Rico. Tel./fax: +1 787 259 7085.

Corresponding Author

Luisa Moraleslmorales@psm.edu

Received 8 January 2013, Revised 12 July 2013, Accepted 20 August 2013, Available Online 12 October 2013.

DOI: 10.1016/j.jegh.2013.08.003 How to use a DOI?
Keywords: Breast cancer; Epidemiology; Risk factors; Protective factors; DNA repair capacity; Receptor status
Abstract: Background: Breast cancer (BC) is the most common cancer afflicting Puerto Rican women and accounts for more cancer-related deaths in this population than any other cancer.

Methods: Demographic, anthropometric, family history, and lifestyle data, as well as DNA repair capacity (DRC), were compared in 465 BC cases and 661 controls. Crude and multiple logistic regression-derived adjusted odds ratios were used as indicators of the associations between BC and the variables under study.

Results: A low DRC level, aging (>61 years), family history of BC, and low education level had statistically significant associations with increased BC risk. Endometriosis, full-term pregnancy at an earlier age, higher parity, hysterectomy before age 50, multivitamin and calcium intake, and longer duration of breastfeeding significantly decreased BC risk.

Conclusions: This study discusses the major risk factors for BC in Puerto Rico (PR). Because many of these findings represent modifiable risk factors, they can translate into public health initiatives to lower BC risk. In addition, the possibility of using DRC as a simple screening tool for BC risk is explored.
Copyright: © 2013 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 3 - 4
Pages: 205 - 215
Publication Date: 2013/10/12
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2013.08.003 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Luisa Morales
AU  - Carolina Alvarez-Garriga
AU  - Jaime Matta
AU  - Carmen Ortiz
AU  - Yeidyly Vergne
AU  - Wanda Vargas
AU  - Heidi Acosta
AU  - Jonathan Ramírez
AU  - Julyann Perez-Mayoral
AU  - Manuel Bayona
PY  - 2013
DA  - 2013/10/12
TI  - Factors associated with breast cancer in Puerto Rican women
JO  - Journal of Epidemiology and Global Health
SP  - 205
EP  - 215
VL  - 3
IS  - 4
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2013.08.003
DO  - 10.1016/j.jegh.2013.08.003
ID  - Morales2013
ER  -

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