Journal of Epidemiology and Global Health

Volume 4, Issue 1, March 2014, Pages 45 - 50

Comparison of Tuberculin Skin Test result and interferon gamma response to human PPD in BCG scar positive and negative children

Authors
Shirin Sayyahfara, *, sayyahfar.sh@iums.ac.ir sayyahfar_shirin@yahoo.com, Abdollah Karimib, Alireza Fahimzadb, Ahmad Reza Shamshiric
aDivision of Pediatric Infectious Diseases, Department of Pediatrics, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran
bDivision of Pediatric Infectious Diseases, Pediatric Infectious Research Center(PIRC), Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
cDentistry Research Institute, Department of Community Oral Health, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding author. Address: Division of Pediatric Infectious Diseases, Department of Pediatrics, Iran University of Medical Sciences, Ali Asghar Children Hospital, Vahid Dastgerdi Street, Shariati Street, Tehran 1919816766, Iran. Tel.: +98 21 22255218; fax: +98 21 22220063.
Corresponding Author
Received 6 May 2013, Revised 1 September 2013, Accepted 3 September 2013, Available Online 9 October 2013.
DOI
10.1016/j.jegh.2013.09.002How to use a DOI?
Keywords
BCG vaccine; Human PPD; Interferon Gamma Release Assay; Tuberculin Skin Test; Vaccine scar
Abstract

Background: The aim of this study is to compare Tuberculin Skin Test (TST) result and interferon gamma response to human PPD (purified protein derivative), in scar positive and scar negative BCG-vaccinated children.

Methods: Between August 2007 and May 2008 a total of 236 children aged 1–168 months (mean 21 months) admitted to Mofid Children’s Hospital, Tehran, Iran, were enrolled in a cross-sectional study. Each patient was examined for BCG vaccine scar and tested with TST and human PPD-based Interferon Gamma Release Assay (IGRA).

Results: Two hundred and twenty one cases out of 236 (44% female, 1–168 months, mean age 21 months) were scar positive of whom 95% TST result was negative. Human PPD-based IGRA was positive in 110 (49.8%), negative in 85 (38.4 %) and indeterminate in 26 (11.8%) of scar positive patients.

Fifteen children (40% female, 1–156 months; mean age 42 months) were scar negative. All the scar negative cases were TST negative. Human PPD-based IGRA was positive in 10 (66.7%), negative in 4 (26.7%) and indeterminate in 1 (6.7%) of scar negative patients.

Conclusions: Immune responsiveness to human PPD antigens in scar positive and negative children may not correspond with results of the Tuberculin Skin Test.

Copyright
© 2013 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
Open Access
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal
Journal of Epidemiology and Global Health
Volume-Issue
4 - 1
Pages
45 - 50
Publication Date
2013/10/09
ISSN (Online)
2210-6014
ISSN (Print)
2210-6006
DOI
10.1016/j.jegh.2013.09.002How to use a DOI?
Copyright
© 2013 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
Open Access
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cite this article

TY  - JOUR
AU  - Shirin Sayyahfar
AU  - Abdollah Karimi
AU  - Alireza Fahimzad
AU  - Ahmad Reza Shamshiri
PY  - 2013
DA  - 2013/10/09
TI  - Comparison of Tuberculin Skin Test result and interferon gamma response to human PPD in BCG scar positive and negative children
JO  - Journal of Epidemiology and Global Health
SP  - 45
EP  - 50
VL  - 4
IS  - 1
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2013.09.002
DO  - 10.1016/j.jegh.2013.09.002
ID  - Sayyahfar2013
ER  -