A longitudinal cohort study of the relationship between Thimerosal-containing hepatitis B vaccination and specific delays in development in the United States: Assessment of attributable risk and lifetime care costs
- 10.1016/j.jegh.2015.06.002How to use a DOI?
- Ethylmercury; Merthiolate; Thimerosal; Thiomersal; Vaccine
Epidemiological evidence suggests a link between mercury (Hg) exposure from Thimerosal-containing vaccines and specific delays in development. A hypothesis-testing longitudinal cohort study (n = 49,835) using medical records in the Vaccine Safety Datalink (VSD) was undertaken to evaluate the relationship between exposure to Hg from Thimerosal-containing hepatitis B vaccines (T-HBVs) administered at specific intervals in the first 6 months of life and specific delays in development [International Classification of Disease, 9th revision (ICD-9): 315.xx] among children born between 1991 and 1994 and continuously enrolled from birth for at least 5.81 years. Infants receiving increased Hg doses from T-HBVs administered within the first month, the first 2 months, and the first 6 months of life were significantly more likely to be diagnosed with specific delays in development than infants receiving no Hg doses from T-HBVs. During the decade in which T-HBVs were routinely recommended and administered to US infants (1991–2001), an estimated 0.5–1 million additional US children were diagnosed with specific delays in development as a consequence of 25 μg or 37.5 μg organic Hg from T-HBVs administered within the first 6 months of life. The resulting lifetime costs to the United States may exceed $1 trillion.
- © 2015 The Authors. Published by Elsevier Ltd. on behalf of Ministry of Health, Saudi Arabia.
- Open Access
- This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Cite this article
TY - JOUR AU - David A. Geier AU - Janet K. Kern AU - Brian S. Hooker AU - Paul G. King AU - Lisa K. Sykes AU - Mark R. Geier PY - 2015 DA - 2015/07/09 TI - A longitudinal cohort study of the relationship between Thimerosal-containing hepatitis B vaccination and specific delays in development in the United States: Assessment of attributable risk and lifetime care costs JO - Journal of Epidemiology and Global Health SP - 105 EP - 118 VL - 6 IS - 2 SN - 2210-6014 UR - https://doi.org/10.1016/j.jegh.2015.06.002 DO - 10.1016/j.jegh.2015.06.002 ID - Geier2015 ER -