Journal of Epidemiology and Global Health

Volume 10, Issue 1, March 2020, Pages 59 - 64

Clinical, Imaging, and Laboratory Characteristics of Adult Mexican Patients with Tuberculous Meningitis: A Retrospective Cohort Study

Authors
Miguel García-Grimshaw1, 2, *, Francisco Alejandro Gutiérrez-Manjarrez3, Samuel Navarro-Álvarez4, Alejandra González-Duarte1
1Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México
2Department of Internal Medicine, Hospital General Tijuana; Tijuana, Baja California, México
3Department of Neurology, Hospital General Tijuana; Tijuana, Baja California, México
4Department of Infectious Diseases, Hospital General Tijuana; Tijuana, Baja California, México
*Corresponding author. Email: miguelgrimshaw@gmail.com
Corresponding Author
Miguel García-Grimshaw
Received 27 July 2019, Accepted 20 October 2019, Available Online 6 November 2019.
DOI
https://doi.org/10.2991/jegh.k.191023.001How to use a DOI?
Keywords
Meningitis, tuberculosis, tuberculous meningitis, meningeal tuberculosis, Mexico, outcome
Abstract

Tuberculous Meningitis (TBM) is the most common form of central nervous system Tuberculosis (TB), accounting for 5–6% of extrapulmonary TB cases. Nowadays, TBM continues to be a major topic in public health because of its high prevalence worldwide. This retrospective study aimed to describe the clinical, laboratory, and imaging characteristics at admission; and in-hospital outcome of adult Mexican patients with TBM. We collected data from medical records of patients aged ≥18 years diagnosed with TBM according to the uniform case definition for clinical research who were treated at Tijuana General Hospital between January 2015 and March 2018 and compared them according to the subtype of diagnosis. We included 41 cases (26 males, median age 28 years, range 18–57 years), 13 (31.7%) patients were HIV positive, and 21 (51.2%) were illicit drug users. At admission, 7 (17.1%) patients were in stage I, 22 (53.6%) in stage II, and 12 (29.3%) in stage III. A definitive diagnosis was established in 23 (56.1%) patients, probable in 14 (34.1%), and possible in four (9.8%). Molecular testing was positive in 83% of the cases, yielding significantly higher positive results than other microbiological studies. There were eight (19.5%) deaths, without statistical difference between mortality and not having a definitive diagnosis (p = 0.109). We found that the baseline characteristics of our population were similar to those described by other authors worldwide. In this series, molecular testing showed to be very useful when used in the early stages, particularly in subjects with subacute onset of headache, fever, weight loss, and altered mental status.

Copyright
© 2019 Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Journal of Epidemiology and Global Health
Volume-Issue
10 - 1
Pages
59 - 64
Publication Date
2019/11/06
ISSN (Online)
2210-6014
ISSN (Print)
2210-6006
DOI
https://doi.org/10.2991/jegh.k.191023.001How to use a DOI?
Copyright
© 2019 Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Miguel García-Grimshaw
AU  - Francisco Alejandro Gutiérrez-Manjarrez
AU  - Samuel Navarro-Álvarez
AU  - Alejandra González-Duarte
PY  - 2019
DA  - 2019/11/06
TI  - Clinical, Imaging, and Laboratory Characteristics of Adult Mexican Patients with Tuberculous Meningitis: A Retrospective Cohort Study
JO  - Journal of Epidemiology and Global Health
SP  - 59
EP  - 64
VL  - 10
IS  - 1
SN  - 2210-6014
UR  - https://doi.org/10.2991/jegh.k.191023.001
DO  - https://doi.org/10.2991/jegh.k.191023.001
ID  - García-Grimshaw2019
ER  -