Journal of Epidemiology and Global Health

Volume 11, Issue 1, March 2021, Pages 124 - 131

Screening Strategy of Active Pulmonary Tuberculosis in Sheltered Homeless People in Marseille, 2019

Authors
Tran Duc Anh Ly1, 2, ORCID, Floriane Holi-Jamovski3, Van Thuan Hoang1, 2, 4, ORCID, Ndiaw Goumballa1, 2, 5, Meriem Louni1, 2, Thi Loi Dao1, 2, 6, ORCID, Michel Drancourt2, 7, Philippe Gautret1, 2, *, ORCID
1Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France
2IHU-Méditerranée Infection, Marseille, France
3Centres de Lutte Antituberculeuse, Marseille, France
4Family Medicine Department, Thai Binh University of Medicine and Pharmacy, Vietnam
5VITROME, Campus International IRD-UCAD de l’IRD, Dakar, Senegal
6Pneumology Department, Thai Binh University of Medicine and Pharmacy, Vietnam
7Aix Marseille Univ, MEPHI, Marseille, France
*Corresponding author. Email: philippe.gautret@club-internet.fr
Corresponding Author
Philippe Gautret
Received 5 July 2020, Accepted 19 September 2020, Available Online 15 October 2020.
DOI
https://doi.org/10.2991/jegh.k.201009.001How to use a DOI?
Keywords
Active pulmonary tuberculosis, tuberculosis-screening questionnaire, chest X-ray, microscopical testing, GeneXpert MTB/RIF assays, culture
Abstract

We aimed to assess the reliability of a screening questionnaire for Active Pulmonary Tuberculosis (APTB) in a population of sheltered homeless persons (HP). Participants from two homeless shelters completed a questionnaire specially designed to identify patients at high-risk of APTB (available at www.tb-screen.ch), underwent a Chest X-ray (CXR), and provided sputum samples. Computed Tomography (CT) scanning was subsequently performed on those which had images consistent with APTB. Microscopical examination, real-time polymerase chain reaction (qPCR) and culture testing were applied for Mycobacterium tuberculosis complex detection. Additionally, we retrospectively selected 16 HP hospitalised in our hospital between 2017 and 2019 with biologically confirmed tuberculosis and typical CXR images, and retrospectively documented a screening questionnaire by reviewing their medical files. Overall, the population (n = 383 HP) was predominantly migrants (87%). Forty-seven individuals (11.7%) had positive screening questionnaire scores and four (2.4%) displayed abnormal CXR features consistent with APTB. Three of them three underwent CT scanning that ruled out APTB and one was lost to follow-up. None tested positive through microbiological investigation. Fifteen (of 16, 93.8%) hospitalised patients with biologically confirmed APTB had a positive screening questionnaire score. The sensitivity and specificity of questionnaire for confirmed APTB were 93.8% and 87.7%, respectively. Screening questionnaires can be used as a first assessment tool in people arriving at homeless shelters and to refer those screening positive for a CXR.

Copyright
© 2020 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Journal of Epidemiology and Global Health
Volume-Issue
11 - 1
Pages
124 - 131
Publication Date
2020/10/15
ISSN (Online)
2210-6014
ISSN (Print)
2210-6006
DOI
https://doi.org/10.2991/jegh.k.201009.001How to use a DOI?
Copyright
© 2020 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Tran Duc Anh Ly
AU  - Floriane Holi-Jamovski
AU  - Van Thuan Hoang
AU  - Ndiaw Goumballa
AU  - Meriem Louni
AU  - Thi Loi Dao
AU  - Michel Drancourt
AU  - Philippe Gautret
PY  - 2020
DA  - 2020/10/15
TI  - Screening Strategy of Active Pulmonary Tuberculosis in Sheltered Homeless People in Marseille, 2019
JO  - Journal of Epidemiology and Global Health
SP  - 124
EP  - 131
VL  - 11
IS  - 1
SN  - 2210-6014
UR  - https://doi.org/10.2991/jegh.k.201009.001
DO  - https://doi.org/10.2991/jegh.k.201009.001
ID  - Ly2020
ER  -