The Role of Convalescent Plasma and Tocilizumab in the Management of COVID-19 Infection: A Cohort of 110 Patients from a Tertiary Care Hospital in Oman
- 10.2991/jegh.k.201222.001How to use a DOI?
- COVID-19; convalescent plasma; tocilizumab; mortality; cytokine storm; Oman
Aim: As Coronavirus Disease-2019 (COVID-19) pandemic continues to evolve, the search for safe and effective therapeutic interventions remain essential.
Methods: We conducted a retrospective cohort study on patients hospitalized with laboratory confirmed severe acute respiratory syndrome coronavirus-2 infection, comparing standard of care along with Convalescent Plasma with or without Tocilizumab (CP vs. CPT).
Results: A total of 110 patients were enrolled with an overall mean age of 50 ± 16 years. Patients on CPT were more likely to have had acute respiratory distress syndrome (77% vs. 42%; p < 0.001), sepsis (9.7% vs. 0; p = 0.036), chest X-ray abnormalities (71% vs. 44%; p = 0.004), intensive care unit admission (84% vs. 56%; p = 0.001) as well as being on mechanical ventilation (79% vs. 48%; p = 0.001). After CPT treatment, all measured inflammatory markers, except interleukine-6, showed an overall steady decline over time (all p-values <0.05) and the ventilatory parameters showed significant improvement of PaO2/FiO2 ratio from 127 to 188 within 7 days (p < 0.001). Additionally, 52% (32/62) of the patients had favorable outcome, either as improvement of ventilatory parameters or extubation within 14 days of hospitalization. However, mortality rate in those on CPT was higher than those who received CP alone (24% vs. 8.3%; p = 0.041).
Conclusion: In patients with severe COVID-19 infection, using tocilizumab with convalescent plasma is associated with improvement in inflammatory and ventilatory parameters but no effect on mortality. These findings require validation from randomized clinical trials.
- © 2020 The Authors. Published by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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TY - JOUR AU - Faryal Khamis AU - Ziad Memish AU - Maher Al Bahrani AU - Hamed Al Nummani AU - Dana Al Raisi AU - Samata Al Dowaiki AU - Shabnam Chhetri AU - Fatma Al Fahdi AU - Maha Al Yahyai AU - Nenad Pandak AU - Zakariya Al Bolushi AU - Zainab Alarimi AU - Sabria Al Hashmi AU - Issa Al Salmi AU - Ibrahim Al-Zakwani PY - 2021 DA - 2021/01/07 TI - The Role of Convalescent Plasma and Tocilizumab in the Management of COVID-19 Infection: A Cohort of 110 Patients from a Tertiary Care Hospital in Oman JO - Journal of Epidemiology and Global Health SP - 216 EP - 223 VL - 11 IS - 2 SN - 2210-6014 UR - https://doi.org/10.2991/jegh.k.201222.001 DO - 10.2991/jegh.k.201222.001 ID - Khamis2021 ER -