Journal of Epidemiology and Global Health

Volume 11, Issue 2, June 2021, Pages 238 - 245

Retrospective Study of Bone-TB in Oman: 2002–2019

Authors
Wael A.H. Hegazy1, 2, *, ORCID, Raqiya Al Mamari2, Khalfan Almazroui3, Ali Al Habsi3, Ahmed Kamona2, Huda AlHarthi3, Areej I. Al Lawati4, AlZahra H. AlHusaini5
1Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
2Department of Pharmacy Practice and pharmaceutical sciences, Pharmacy Program, Oman College of Health Sciences, Muscat, Sultanate of Oman
3Pharmacy and Medical Store Department, Clinical Pharmacy Section, Directorate General of Khoula Hospital, Muscat, Sultanate of Oman
4Pharmacy and Medical Store Department, Directorate General of Royal Hospital, Muscat, Sultanate of Oman
5Directorate of Drug Store, Injection Section, Directorate General of Medical Supplies, Muscat, Sultanate of Oman
*Corresponding author. Email: waelmhegazy@daad-alumni.de
Corresponding Author
Wael A.H. Hegazy
Received 21 December 2020, Accepted 7 April 2021, Available Online 26 April 2021.
DOI
https://doi.org/10.2991/jegh.k.210420.002How to use a DOI?
Keywords
Tuberculosis; extra-pulmonary tuberculosis; Bone-TB; Oman
Abstract

Objective: Little information is available about the etiology, pathophysiology, risk factors, and epidemiologic features of Bone Tuberculosis (Bone-TB). In this work, we present the epidemiological data about the Bone-TB in the Sultanate of Oman.

Methods: Retrospectively, we identified and assessed those patients who were diagnosed with Bone-TB between January 2002 and December 2019 at Khoula Hospital. The following data were collected: demographics, clinical presentation, anatomical location, diagnosis, and treatment of the Bone-TB.

Results: During the study period, 115 cases of Bone-TB were diagnosed. Males were affected more than females (57.4% and 42.6%, respectively). About 30% of Bone-TB cases were primary diagnosed in other organs particularly the lungs and then after disseminated to the bone. However, the Bone-TB was detected in hip, leg, hand, shoulder, and skull bones, the most detected Bone-TB was in spine (66% of cases). After vaccination the Bacillus Calmette–Guérin (BCG) strains were identified in the bones of eight babies. Tubercle bacilli were detected by Acid-Fast Stain (AFS) in 59% of cases, and the rest of cases were confirmed using polymerase chain reaction (PCR) tests. There are two used treatment regimens, with 12.4% relapse. The gastrointestinal tract (GIT) disturbances were the most related side effects. The resistance has been detected to pyrazinamide in six cases, rifampicin in three cases, and isoniazid, streptomycin and kanamycin were detected in one case.

Conclusion: The most predominant Bone-TB cases were spine-TB that were mainly disseminated from the lungs. AFS failed to detect tubercle bacilli in 40% of cases. There is no statistical significance in relapse between the used two regimens. The death was predominant among skull-TB cases.

Copyright
© 2021 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Journal of Epidemiology and Global Health
Volume-Issue
11 - 2
Pages
238 - 245
Publication Date
2021/04/26
ISSN (Online)
2210-6014
ISSN (Print)
2210-6006
DOI
https://doi.org/10.2991/jegh.k.210420.002How to use a DOI?
Copyright
© 2021 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Wael A.H. Hegazy
AU  - Raqiya Al Mamari
AU  - Khalfan Almazroui
AU  - Ali Al Habsi
AU  - Ahmed Kamona
AU  - Huda AlHarthi
AU  - Areej I. Al Lawati
AU  - AlZahra H. AlHusaini
PY  - 2021
DA  - 2021/04/26
TI  - Retrospective Study of Bone-TB in Oman: 2002–2019
JO  - Journal of Epidemiology and Global Health
SP  - 238
EP  - 245
VL  - 11
IS  - 2
SN  - 2210-6014
UR  - https://doi.org/10.2991/jegh.k.210420.002
DO  - https://doi.org/10.2991/jegh.k.210420.002
ID  - Hegazy2021
ER  -