Materials Highlights

In Press, Corrected Proof, Available Online: 14 December 2020

Inkjet Printed Melatonin on Poly(vinyl alcohol) Oral Films: Uptake in an Ex Vivo Oral Mucosal Pellicle Model

Authors
Yin Ming Khor1, Simon Gaisford2, Guy Howard Carpenter3, Bahijja Tolulope Raimi-Abraham1, *
1Faculty of Life Sciences and Medicine, Institute of Pharmaceutical Science, Drug Delivery Group, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
2University College London, School of Pharmacy, 29 – 39 Brunswick Square, London WC1N 1AX, UK
3Salivary Research, Centre of Host-Microbial Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
*Corresponding author. Email: Bahijja.Raimi-Abraham@kcl.ac.uk
Corresponding Author
Bahijja Tolulope Raimi-Abraham
Received 11 August 2020, Accepted 30 November 2020, Available Online 14 December 2020.
DOI
https://doi.org/10.2991/mathi.k.201206.001How to use a DOI?
Keywords
Melatonin, inkjet printing, mucosal pellicle, TR146 cells, drug delivery
Abstract

There is a growing interest in the use of melatonin in preventing radiation-induced mucositis with potential beneficial effects including prevention of mucosal damage, the emergence of ulcers and the loss of proliferative progenitor stem cells caused by radiation. Local drug delivery to the oral cavity is influenced by the oral mucosal pellicle which serves as a protective barrier between the oral epithelial surface and the external environment. In this study, we explore two key areas. Firstly, the use of thermal inkjet printing to improve the precision of drug deposition on polymeric oral films. Secondly, investigate melatonin release and penetration across an ex vivo oral mucosal pellicle model into the epithelial cancer cell line (TR146 cells). Our findings show that the deposited melatonin crystallized on the surface of the Polyvinyl Alcohol (PVA) film as the jetted droplets dried, consistent with previous work on in-jetted pharmaceutical solutions. The solid state of the deposited melatonin was further confirmed in attenuated total reflection Fourier transform infrared studies as crystalline. In addition, no new bonds detected which indicates the absence of new chemical bonds and interactions between melatonin and PVA. Investigating melatonin release and penetration across ex vivo oral mucosal pellicle model into the epithelial cancer cell line (TR146 cells) found that the amount of melatonin released was lower in the presence of saliva, likely due to the saliva initiating the formation of the mucosal pellicle through mucin–mucin interactions.

Copyright
© 2020 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Materials Highlights
Publication Date
2020/12
ISSN (Online)
2666-4933
DOI
https://doi.org/10.2991/mathi.k.201206.001How to use a DOI?
Copyright
© 2020 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Yin Ming Khor
AU  - Simon Gaisford
AU  - Guy Howard Carpenter
AU  - Bahijja Tolulope Raimi-Abraham
PY  - 2020
DA  - 2020/12
TI  - Inkjet Printed Melatonin on Poly(vinyl alcohol) Oral Films: Uptake in an Ex Vivo Oral Mucosal Pellicle Model
JO  - Materials Highlights
SN  - 2666-4933
UR  - https://doi.org/10.2991/mathi.k.201206.001
DO  - https://doi.org/10.2991/mathi.k.201206.001
ID  - Khor2020
ER  -