Proceedings of the International Conference on Advances in Energy, Environment and Chemical Engineering

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Synthetic Study towards Entecavir

Authors
Shuangjie Lin, Feifei Huang, Shenkun Yang, Shuangping Huang, Xiaoji Wang
Corresponding Author
Shuangjie Lin
Available Online September 2015.
DOI
10.2991/aeece-15.2015.173How to use a DOI?
Keywords
Entecavir; synthesis; HBV
Abstract

A synthetic design of Entecavir was described, and the intermediate, (S)-N-methoxy -3-((4-methoxybenzyl)oxy)-N-methylpent-4-enamide, was synthesized using acrylaldehyde as the starting material, which was obtained via an Evans Aldol reaction, Weinreb amide formation, and a PMB protection.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the International Conference on Advances in Energy, Environment and Chemical Engineering
Series
Advances in Engineering Research
Publication Date
September 2015
ISBN
10.2991/aeece-15.2015.173
ISSN
2352-5401
DOI
10.2991/aeece-15.2015.173How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Shuangjie Lin
AU  - Feifei Huang
AU  - Shenkun Yang
AU  - Shuangping Huang
AU  - Xiaoji Wang
PY  - 2015/09
DA  - 2015/09
TI  - Synthetic Study towards Entecavir
BT  - Proceedings of the International Conference on Advances in Energy, Environment and Chemical Engineering
PB  - Atlantis Press
SP  - 840
EP  - 843
SN  - 2352-5401
UR  - https://doi.org/10.2991/aeece-15.2015.173
DO  - 10.2991/aeece-15.2015.173
ID  - Lin2015/09
ER  -