Structure and Antibacterial Activity of Bi-cyclohexanone Pentaerythritol Ketal

DOI

10.2991/ame-16.2016.213How to use a DOI?

Keywords

Cyclohexanone pentaerythritol ketal, X-ray structure, antibacterial activity

Abstract

Cyclohexanone pentaerythritol ketal was synthesized from cyclohexanone and pentaerythritol by condensation using NaHSO4 as catalyst and characterized by NMR and MS spectrum. Furthermore, the structure of the tile compound was confirmed by single-crystal X-ray diffraction. It crystallizes in orthorhombic space group, P 21, with a unit cell dimensions of a = 11.1214(9) Å, b = 13.9216(6) Å and c = 11.6658(10) Å. In the crystal, there are two independent molecules with different conformation, varying both in bond lengths and angles. In each molecular, there are four six-membered cycles, two cyclohexyl groups and two 1,3-dioxane groups. The four six-membered cycles all display a typical stable boat conformation. The stacking interaction is responsible for the crystal's 1-D supra-molecular structure. The thermal gravimetric analysis (TGA) indicates the title compound is stable below 200°C, and the remaining weight ratio is less than 9% above 300°C. This compound was evaluated for their in vitro antimicrobial activity against six bacteria (S. aureus, S. epidermidis, M. luteus, E. coli, K. pneumoniae, A. fumigatus). It some anti-inflammatory activity against the tested bacteria and the inhibition is depending on the concentration.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Li Huang
PY  - 2016/06
DA  - 2016/06
TI  - Structure and Antibacterial Activity of Bi-cyclohexanone Pentaerythritol Ketal
BT  - Proceedings of the 2nd Annual International Conference on Advanced Material Engineering (AME 2016)
PB  - Atlantis Press
SP  - 1315
EP  - 1320
SN  - 2352-5401
UR  - https://doi.org/10.2991/ame-16.2016.213
DO  - 10.2991/ame-16.2016.213
ID  - Huang2016/06
ER  -