Recent Progress in High Shear Wet Granulation Process
Ning Zhou, Liangshan Ming, Kai Li, Xiao Cheng, Zhe Li
Available Online April 2016.
- 10.2991/amsee-16.2016.11How to use a DOI?
- review; high shear granulation; wetting and nucleation; consolidation and growth; and breakage and attrition
High shear wet granulation is widely used in the pharmaceutical industry, however it is still difficult to predict the results of granulation and explain the relevant results. The paper reviews the three key processes in high shear granulation: wetting and nucleation, consolidation and growth, and breakage and attrition, combines with the corresponding models, the dimensionless parameters, regime maps and related mechanisms. Summarizes the basis and methods for judgment of granulation endpoint of final product. And proposed future direction of development of granulation and research ideas, which helps to solve the existing problems in the production and accelerate its development.
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Ning Zhou AU - Liangshan Ming AU - Kai Li AU - Xiao Cheng AU - Zhe Li PY - 2016/04 DA - 2016/04 TI - Recent Progress in High Shear Wet Granulation Process BT - Proceedings of the 2016 International Conference on Advanced Materials Science and Environmental Engineering PB - Atlantis Press SP - 37 EP - 40 SN - 2352-5401 UR - https://doi.org/10.2991/amsee-16.2016.11 DO - 10.2991/amsee-16.2016.11 ID - Zhou2016/04 ER -