Simple Synthesis of Fluorophore Using Water-Soluble Chitosan Oligomer
- 10.2991/amsm-16.2016.98How to use a DOI?
- chitosan oligomer; silver chloride nanoparticle; fluorescent
In the past few decades, a great interest has been focused on a naturally occurring class of polymers called chitosan for their large amount in nature, biodegradability and extensive applications. Water-soluble chitosan oligomer is composed of " "-(1,4)-2-amido-2-deoxy-D-glucan and " "-(1,4)-2-acetoamido-2-deoxy-D-glucan(acetylglucosamine), and the low molecular weight substances obtained by acidic or enzymatic hydrolysis of chitosan. Until now, many researchers have examined chitosan oligomer as a promising material for biomedical applications on account of its good biocompatibility, biodegradability, antimicrobial activity and wound healing effects. Dye-labeled chitosan can be also employed in bio-imaging system, because it has low toxicity. Some dyes, such as Alexa Fluor, Cibacron Blue and fluorescein isothiocyanate (FITC), have been employed to create dye-labeled chitosan particulate systems. However, a greater part of approaches have been developed for the synthesis of dye-labeled chitosan molecular system using chemical reagents due to its low solubility. Numerous researches have addressed the utilization of chitosan as a fluorescence probe. These methods have a limited application in the medical and pharmaceutical fields, because most of them may be environmentally toxic or biologically hazardous. Herein, we focused on the environmentally friendly approach using a water-soluble chitosan derivative for bio-imaging. We report on the simple synthesis and optical properties for FITC-labeled chitosan oligomer in distilled water.
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Hun Min Lee AU - Ja Young Cheon AU - Seoho Lee AU - Seung Hyun Lee AU - Su Young Kim AU - Dong Hoon Kang AU - Jeong Woo Heo AU - Won Ho Park PY - 2016/05 DA - 2016/05 TI - Simple Synthesis of Fluorophore Using Water-Soluble Chitosan Oligomer BT - Proceedings of the 2016 International Conference on Applied Mathematics, Simulation and Modelling PB - Atlantis Press SP - 435 EP - 436 SN - 2352-538X UR - https://doi.org/10.2991/amsm-16.2016.98 DO - 10.2991/amsm-16.2016.98 ID - Lee2016/05 ER -