Simple Synthesis of Fluorophore Using Water-Soluble Chitosan Oligomer

DOI

10.2991/amsm-16.2016.98How to use a DOI?

Keywords

chitosan oligomer; silver chloride nanoparticle; fluorescent

Abstract

In the past few decades, a great interest has been focused on a naturally occurring class of polymers called chitosan for their large amount in nature, biodegradability and extensive applications. Water-soluble chitosan oligomer is composed of " "-(1,4)-2-amido-2-deoxy-D-glucan and " "-(1,4)-2-acetoamido-2-deoxy-D-glucan(acetylglucosamine), and the low molecular weight substances obtained by acidic or enzymatic hydrolysis of chitosan. Until now, many researchers have examined chitosan oligomer as a promising material for biomedical applications on account of its good biocompatibility, biodegradability, antimicrobial activity and wound healing effects. Dye-labeled chitosan can be also employed in bio-imaging system, because it has low toxicity. Some dyes, such as Alexa Fluor, Cibacron Blue and fluorescein isothiocyanate (FITC), have been employed to create dye-labeled chitosan particulate systems. However, a greater part of approaches have been developed for the synthesis of dye-labeled chitosan molecular system using chemical reagents due to its low solubility. Numerous researches have addressed the utilization of chitosan as a fluorescence probe. These methods have a limited application in the medical and pharmaceutical fields, because most of them may be environmentally toxic or biologically hazardous. Herein, we focused on the environmentally friendly approach using a water-soluble chitosan derivative for bio-imaging. We report on the simple synthesis and optical properties for FITC-labeled chitosan oligomer in distilled water.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hun Min Lee
AU  - Ja Young Cheon
AU  - Seoho Lee
AU  - Seung Hyun Lee
AU  - Su Young Kim
AU  - Dong Hoon Kang
AU  - Jeong Woo Heo
AU  - Won Ho Park
PY  - 2016/05
DA  - 2016/05
TI  - Simple Synthesis of Fluorophore Using Water-Soluble Chitosan Oligomer
BT  - Proceedings of the 2016 International Conference on Applied Mathematics, Simulation and Modelling
PB  - Atlantis Press
SP  - 435
EP  - 436
SN  - 2352-538X
UR  - https://doi.org/10.2991/amsm-16.2016.98
DO  - 10.2991/amsm-16.2016.98
ID  - Lee2016/05
ER  -