Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

A Novel, Non-Cytotoxic, Anti-Invasive Therapeutic Agent for Ovarian Cancer

Authors
S.D. Swenson, F.S. Markland, R. Minea
Corresponding Author
S.D. Swenson
Available Online July 2016.
DOI
https://doi.org/10.2991/bbe-16.2016.27How to use a DOI?
Keywords
Ovarian Cancer, Integrins, Disintegrins, Intraperitoneal Delivery, Targeted Therapy.
Abstract
The 5-year survival is only about 30% when ovarian cancer (OC) is first detected at an advanced stage, which is the case for ~70% of women with OC. The combination of debulking surgery and cytotoxic chemotherapy is the primary treatment modality for OC. There has been much interest in the use of intraperitoneal (IP) chemotherapy for OC and the National Cancer Institute of the USA has endorsed this form of therapy. Disintegrins represent a class of disulfide-rich polypeptides, originally isolated from snake venom, many of which contain a cyclic-Arg-Gly-Asp (c-RGD) motif. Due to their ability to bind to integrins that are important to cancer progression and dissemination, disintegrins hold a significant translational potential as anti-cancer therapeutic agents. Integrins are heterodimeric adhesion receptors on the surface of cells that relay signals bi-directionally across the plasma membrane between the extracellular matrix and cytoskeletal proteins and signaling molecules inside the cell. They are closely associated with OC progression and dissemination. Multiple studies have demonstrated that adding IP therapy to intravenous therapy produces survival benefits in patients with advanced OC. We report the use of IP delivery of a recombinant disintegrin, vicrostatin (VCN), in mouse models of OC, which leads to highly effective inhibition of progression and dissemination of OC. When impregnated in a gel formulation VCN has extended time-release activity and retains therapeutic levels for 7-10 days; with weekly VCN injections activity is retained for prolonged times. This IP delivered formulation is effective against several human ovarian cancer cell lines, and warrants further translational studies.
Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)

Proceedings
International Conference on Biomedical and Biological Engineering
Part of series
Advances in Biological Sciences Research
Publication Date
July 2016
ISBN
978-94-6252-216-9
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbe-16.2016.27How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - S.D. Swenson
AU  - F.S. Markland
AU  - R. Minea
PY  - 2016/07
DA  - 2016/07
TI  - A Novel, Non-Cytotoxic, Anti-Invasive Therapeutic Agent for Ovarian Cancer
BT  - International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.27
DO  - https://doi.org/10.2991/bbe-16.2016.27
ID  - Swenson2016/07
ER  -