Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

Effects of Tonifying Kidney and Spleen, Detoxification of Throat for Th1 /Th2 of IgA Nephropathy Model Rats

Authors
Di Zou, Dongmei Zhang, Yinping Wang, Shoulin Zhang
Corresponding Author
Di Zou
Available Online July 2016.
DOI
https://doi.org/10.2991/bbe-16.2016.32How to use a DOI?
Keywords
Tonifying kidney and spleen, Detoxification of throat, IgA nephropathy, Cytokines, Th1 / Th2
Abstract
Purposes:to investigate the effects of tonifying kidney and spleen, detoxification of throat for Th1 /Th2 of IgA nephropathy model rats.Methods : 72 rats were randomly divided into blank group, model group, Tripterygium wilfordii multi glycoside tablet group (control group), tonifying kidney and spleen, detoxification of throat the medicine low, middle and high dose group, referring to reports of Huiyu Lu,such as the method of preparation of animal model, the fluorescent light semi quantitative method for detection of rat renal tissue membrane IgA deposition, enzyme linked immunosorbent assays (ELISA) for detection of ratexpression level of serum cytokines interleukin prime (IL) IL-2, IL-4, IL-10, interference prime (INF) - . Results:After the model results showed varying degrees of poor appetite, hair messy, weight loss, kidney mesangial IgA deposition.The treatment group rat IgA deposition has been reduced. Compared with the blank group, the model group rats serum IL-2 and INF- levels were significantly lower (P0.05). Conclusion:IgAN model rat cytokine IL-2, IL-4, IL-10, INF- expression disorder and Th1/Th2 drift and the method of tonifying kidney and spleen, detoxification of throat can adjust the expression levels of cytokines IL-2, IL-4, IL-10 and INF- , and correct theTh2 / Th1 ratio drift.
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Proceedings
International Conference on Biomedical and Biological Engineering
Part of series
Advances in Biological Sciences Research
Publication Date
July 2016
ISBN
978-94-6252-216-9
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbe-16.2016.32How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Di Zou
AU  - Dongmei Zhang
AU  - Yinping Wang
AU  - Shoulin Zhang
PY  - 2016/07
DA  - 2016/07
TI  - Effects of Tonifying Kidney and Spleen, Detoxification of Throat for Th1 /Th2 of IgA Nephropathy Model Rats
BT  - International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.32
DO  - https://doi.org/10.2991/bbe-16.2016.32
ID  - Zou2016/07
ER  -