Influence of Daidzein and Daidzein Metabolites on Lifespan and Stress Resistance in Caenorhabditis Elegans
Ye Wang, Xiaolei Li, Conghui Zhang, Xiuling Wang
Available Online July 2016.
- https://doi.org/10.2991/bbe-16.2016.39How to use a DOI?
- Daidzein, Daidzein metabolites, C. elegans, Lifespan, Stress resistance
- Caenorhabditis elegans (C. elegans) was used as an animal model to study the influence of isoflavone daidzein and daidzein metabolites, including dihydrodaidzein (DHD), O-desmethylangolensin (O-Dma) and equol, on lifespan in C. elegans at the concentration of 0.1 mmol/L. The results showed that equol significantly increased the lifespan of C. elegans; however, O-Dma significantly shortened the lifespan of C. elegans. No obvious difference in lifespan was observed when the worms were exposed to daidzein and DHD, respectively. Further study on stress resistance demonstrated that both the thermal and oxidative stress tolerance capacity of C. elegans was significantly enhanced after being exposed to equol.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Ye Wang AU - Xiaolei Li AU - Conghui Zhang AU - Xiuling Wang PY - 2016/07 DA - 2016/07 TI - Influence of Daidzein and Daidzein Metabolites on Lifespan and Stress Resistance in Caenorhabditis Elegans BT - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering PB - Atlantis Press SP - 232 EP - 237 SN - 2468-5747 UR - https://doi.org/10.2991/bbe-16.2016.39 DO - https://doi.org/10.2991/bbe-16.2016.39 ID - Wang2016/07 ER -