Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

The Osteoprotective Effect of Zhuanggu-Guanjie Pill in Orchidectomized Mice

Authors
Xiaomei Yuan, Yanan Bi, Zeman Yan, Hong Shi, Kun Zhou
Corresponding Author
Xiaomei Yuan
Available Online July 2016.
DOI
https://doi.org/10.2991/bbe-16.2016.44How to use a DOI?
Keywords
Zhuanggu-Guanjie Pill, Male, Mice, Osteoporosis.
Abstract
To verify the osteoprotective effect of Zhuanggu-Guanjie (ZGGJ) in male mice. The male mice were randomly divided into 6 groups: control group (sham-operation), model group (orchidectomy group), three ZGGJ groups at doses of 0.77, 1.54 and 3.08g/kg, as well as Alendronate sodium group as positive control. ZGGJ was intragastric administration daily for 8 weeks until mice were executed followed anesthesia. ZGGJ can ameliorate osteoporosis with increasing bone strength and improve trabecular bone microstructure which was proved by the Micro-CT scan. Serum osteocalcin (OC), alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRACP) were examined, and the decreased OC implied the reduction of bone destruction. These results suggest that ZGGJ pill has significant therapeutic effect on osteoporosis in orchidectomized mice.
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This is an open access article distributed under the CC BY-NC license.

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Proceedings
International Conference on Biomedical and Biological Engineering
Part of series
Advances in Biological Sciences Research
Publication Date
July 2016
ISBN
978-94-6252-216-9
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbe-16.2016.44How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Xiaomei Yuan
AU  - Yanan Bi
AU  - Zeman Yan
AU  - Hong Shi
AU  - Kun Zhou
PY  - 2016/07
DA  - 2016/07
TI  - The Osteoprotective Effect of Zhuanggu-Guanjie Pill in Orchidectomized Mice
BT  - International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.44
DO  - https://doi.org/10.2991/bbe-16.2016.44
ID  - Yuan2016/07
ER  -