Valvular Heart Disease-Related Feed-Forward Loop Network Reveals Some Biological Features for Disease Development

DOI

10.2991/bbe-17.2017.15How to use a DOI?

Keywords

Valvular heart disease (VHD), MicroRNA (miRNA), Transcription factor (TF), Gene, Feed-forward loop network (FFL).

Abstract

This study is to uncover VHD-related important biological features for understanding molecular of this disease. The system analysis strategy is applied to generate the first VHD-related FFL network. Then, the network topology is mapped into the biological space to refine the biological features of VHD. 4 miRNA, 4 TF and 34 gene hubs are identified and confirmed to play important roles in the occurrence and development of VHD. The signal pathways mediated by miRNA hubs are also predicted, where the processes that MAPK pathway mediated by has-let-7c induces VHD are explained. This study provides some new computational evidences for the understanding of VHD molecular mechanism, and also has important implications in terms of improving current therapeutic strategies of VHD.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Feng YANG
AU  - Ke LIU
AU  - Wei ZENG
AU  - Guang-bin WANG
AU  - Zheng-wen LI
AU  - Ke-li HUANG
AU  - Ni-ni RAO
PY  - 2017/05
DA  - 2017/05
TI  - Valvular Heart Disease-Related Feed-Forward Loop Network Reveals Some Biological Features for Disease Development
BT  - Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
PB  - Atlantis Press
SP  - 90
EP  - 98
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-17.2017.15
DO  - 10.2991/bbe-17.2017.15
ID  - YANG2017/05
ER  -