Proceedings of the 4th Borobudur International Symposium on Humanities and Social Science 2022 (BIS-HSS 2022)

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The Role of Genetic Mutation on Schizophrenia: A Basic Review Prior to Pharmacogenomics

Authors
Dhea Nur Hikmah1, Alfian Syarifuddin1, Setiyo Budi Santoso1, Ratna Wijayatri1, Imron Wahyu Hidayat1, *
1Universitas Muhammadiyah Magelang, Magelang, Indonesia
*Corresponding author. Email: imronwh@unimma.ac.id
Corresponding Author
Imron Wahyu Hidayat
Available Online 10 October 2023.
DOI
10.2991/978-2-38476-118-0_96How to use a DOI?
Keywords
Bioinformatical; GWAS; Genome
Abstract

A bioinformatic approach is used to identify indications of reposition drug. It drives newer methods to treating schizophrenia by comparing the binding profiles of currently available clinical compounds to targets or groups of targets derived based on genome-wide association studies (GWAS). Here in, we present the molecular expression of schizophrenia due to polymorphism. The study involves papers indexed by Scopus, and the search uses a combination of the following keyword variants; “GWAS” AND “genom” AND schizophrenia, “GWAS” AND “repurposing drug” AND “schizophrenia”. This study only used original articles in English peer-reviewed journals published during 2022. Thus, the screening results of sources were narrowed to 5 original articles that met the inclusion criteria. We identified 9 genes involved in pathophysiology of schizophrenia. Interestingly, a number of genes have been discovered as being the druggable target. Publications on drug repurposing for schizophrenia treatment suggest possible medication candidates such as verapamil, cinnarizine, nicotine, varenicline, galantamine, and DPP4 inhibitors metoclopramide, trifluoperazine, and neratinib.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 4th Borobudur International Symposium on Humanities and Social Science 2022 (BIS-HSS 2022)
Series
Advances in Social Science, Education and Humanities Research
Publication Date
10 October 2023
ISBN
10.2991/978-2-38476-118-0_96
ISSN
2352-5398
DOI
10.2991/978-2-38476-118-0_96How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Dhea Nur Hikmah
AU  - Alfian Syarifuddin
AU  - Setiyo Budi Santoso
AU  - Ratna Wijayatri
AU  - Imron Wahyu Hidayat
PY  - 2023
DA  - 2023/10/10
TI  - The Role of Genetic Mutation on Schizophrenia: A Basic Review Prior to Pharmacogenomics
BT  - Proceedings of the 4th Borobudur International Symposium on Humanities and Social Science 2022 (BIS-HSS 2022)
PB  - Atlantis Press
SP  - 835
EP  - 847
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-118-0_96
DO  - 10.2991/978-2-38476-118-0_96
ID  - Hikmah2023
ER  -