Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory of Malvidin and its Glycosides from Vaccinium Ashei

DOI

10.2991/bst-17.2018.25How to use a DOI?

Keywords

Blueberry, Malvidin and glycosides, Anti-inflammation, ACE inhibitor, Endothelial cells.

Abstract

Protective effects of malvidin and the glycosides from Vaccinium ashei on endothelial cells were investigated. The results showed that malvidin, malvidin-3-glucoside, malvidin-3-galactoside, and their mixture could defend endothelial cells from damage caused by TNF- , and inhibit monocyte chemotactic protein-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and angiotensin I-converting enzyme expression. In addition, they could inhibit degradation of I B and obstruct the nuclear translocation of p65, suggesting the anti-inflammatory mechanism of NF- B pathway. The results indicated blueberry anthocyanins could be potential inflammation and ACE inhibitors, and blueberry could be functional foods advantageous to maintain a healthy cardiovascular population.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Han Wu
AU  - Zheng Yan
AU  - Wu-Yang Huang
PY  - 2018/02
DA  - 2018/02
TI  - Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory of Malvidin and its Glycosides from Vaccinium Ashei
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 168
EP  - 176
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.25
DO  - 10.2991/bst-17.2018.25
ID  - Wu2018/02
ER  -