Supplementation of Isomalto-oligosaccharide Reduced Colon Cancer-related Bacteria Enzymes and Fecal Toxicity in Nursing-home Residents

DOI

10.2991/bst-17.2018.26How to use a DOI?

Keywords

Isomalto-oligosaccharide, Colorectal cancer, Nursing home -glucuronidase, Mucinase, Bile acid, Cytotoxicity.

Abstract

This study investigated effects of 2-month isomalto-oligosaccharide (IMO) supplementation on fecal colonic bacterial enzymes, bile acid metabolites, and fecal toxicity in the nursing-home residents. Twelve nursing-home residents (mean age 85.2 1.9 y. o.) participated in the placebo-controlled and diet-controlled study. This experiment consisted of a 1-month placebo, 2-month IMO (10 g indigestible oligosaccharide/d) and 1 month post (IMO withdrawal) period. Stool samples were collected for analyses of glucuronidase, mucinase, bile acids and cytotoxicity. The fecal glucuronidase and mucinase activity was significantly lowered by 32% and 22%, respectively, with 1 month of IMO supplementation. The fecal glucuronidase and mucinase activity was furthermore reduced by 38% and 39% with 2-month supplementation. Two-month IMO supplementation significantly decreased the fecal deoxycholic acid, a secondary bile acid related to colon cancer incidence by 57% and beneficially reduced the relative proportion of the secondary bile acid from 75.1% to 52.6%. Overall, one-month IMO supplementation was sufficient to decrease the cytotoxicity of fecal water with 3-h of co-incubation time. This human trial suggested that IMO (10 g/d) could effectively improve colonic ecology and reduce the colon cancer risk markers.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hsiao-Ling Chen
PY  - 2018/02
DA  - 2018/02
TI  - Supplementation of Isomalto-oligosaccharide Reduced Colon Cancer-related Bacteria Enzymes and Fecal Toxicity in Nursing-home Residents
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 177
EP  - 181
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.26
DO  - 10.2991/bst-17.2018.26
ID  - Chen2018/02
ER  -