3-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole

DOI

10.2991/bst-17.2018.35How to use a DOI?

Keywords

3-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole, synthesis

Abstract

3-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole is an important intermediate in many bioactive compounds, such as osimertinib. In this task, a new intermediate is synthesized (a fluorine attached to the pyrimidine ring). The compound is synthesized from commercially available 1H-indole through two-step substitution. The structures and the synthetic route were determined by MS and 1HNMR.And the synthetic method was optimized. The method for synthesizing 3- (2-chloro-5-fluoropyrimidin-4-yl) -1-methyl-1H-indole has low environmental pollution and high purity of the synthesized product.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Wen-Sheng Zou
AU  - Hong Zhang
AU  - Shuang Jia
AU  - Wu-Fu Zhu
AU  - Shan Xu
PY  - 2018/02
DA  - 2018/02
TI  - 3-(2-chloro-5-fluoropyrimidin-4-yl)-1-methyl-1H-indole
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 239
EP  - 242
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.35
DO  - 10.2991/bst-17.2018.35
ID  - Zou2018/02
ER  -