Synthesis of 4-(pyrrolidin-1-ylmethyl)benzaldehyde

DOI

10.2991/bst-17.2018.37How to use a DOI?

Keywords

4-(pyrrolidin-1-ylmethyl)benzaldehyde, Synthesis, Optimized

Abstract

4-(pyrrolidin-1-ylmethyl)benzaldehyde (1) as a water-soluble aldehyde is an important intermediate for small molecule anticancer drugs. A rapid and high yield synthetic method for 4-(pyrrolidin-1-ylmethyl)benzaldehyde (1) was established in this work. The target compound was synthesized from the commercially available terephthalaldehyde (6) through three steps including acetal reaction, nucleophilic reaction and hydrolysis reaction. The structure of the target product was confirmed by 1H NMR and MS. In addition, the synthetic method was optimized. The total yield of the three steps was high up to 68.9%.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Bin-Liang Zhang
AU  - Lu-Jie Cao
AU  - Shan Xu
AU  - Ping Wang
PY  - 2018/02
DA  - 2018/02
TI  - Synthesis of 4-(pyrrolidin-1-ylmethyl)benzaldehyde
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 247
EP  - 250
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.37
DO  - 10.2991/bst-17.2018.37
ID  - Zhang2018/02
ER  -