CdSe Quantum dots Molecular Beacon Hybridization with Target Telomerase DNA Specificity

DOI

10.2991/icaemt-15.2015.175How to use a DOI?

Keywords

Cdse Quantum Dots, Molecular Beacon, Telomerase DNA, One-Pot Approach

Abstract

Quantum Dots are powerful imaging and tracking tools for a wide range of biomedical applications, especially in preparing molecular beacons, but its use is limited by the sensitivity of the electrostatic binding between streptavidin and QDs. In this investigation, we used EDC as a crosslinker and NHS as a stabilizer to activate the carboxyl groups of carboxyl-modified CdSe QDs for direct reaction with primary amines of amino-modified single-stranded DNA. The results suggest that CdSe QDs can be applied for preparing the molecular beacon hybridized with specific telomerase DNA.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Linyan Shen
AU  - Ming Ying
AU  - Pengfei Deng
PY  - 2015/08
DA  - 2015/08
TI  - CdSe Quantum dots Molecular Beacon Hybridization with Target Telomerase DNA Specificity
BT  - Proceedings of the 2015 International Conference on Advanced Engineering Materials and Technology
PB  - Atlantis Press
SP  - 925
EP  - 928
SN  - 2352-5401
UR  - https://doi.org/10.2991/icaemt-15.2015.175
DO  - 10.2991/icaemt-15.2015.175
ID  - Shen2015/08
ER  -