Proceedings of the 2013 International Conference on Advanced ICT and Education

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A Powerful Approach of Live Digital Data Communication in Biomedical Research and Teaching:Detection of Various Impaired Vascular Perfusion in Zebrafish Knockdown Models by Video Imaging

Authors
Ping-Pin Zheng, Rob Willemsen, Johan M Kros
Corresponding Author
Ping-Pin Zheng
Available Online August 2013.
DOI
10.2991/icaicte.2013.173How to use a DOI?
Keywords
video imaging, blood circulation, zebrafish
Abstract

There are various zebrafish models with cardiovascular defects which adequately mimic the impaired circulation and tissue perfusion of various human cardiovascular diseases. Zebrafish embryos/larvae are optically transparent, and the systemic blood circulation can be recorded by using a microscope with video imaging. We detected a series of circulatory defects in our caldesmon and glucose transport 1 knockdown zebrafish models, including arteriovenous (AV) shunting, collateral circulation, AV fusion, vessel bifurcation, reduced or depleted regional perfusion, sinus venous (SV) rupture, and more. The quick detection by simple video imaging of various pathological states of the blood circulation in the living zebrafish embryos/larvae is non-invasive and cost-effective. The method is suitable for large scale screening of altered blood circulation in various zebrafish models with impaired cardiovascular development. This is a powerful approach of live digital data communication in biomedical research and teaching.

Copyright
© 2013, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2013 International Conference on Advanced ICT and Education
Series
Advances in Intelligent Systems Research
Publication Date
August 2013
ISBN
10.2991/icaicte.2013.173
ISSN
1951-6851
DOI
10.2991/icaicte.2013.173How to use a DOI?
Copyright
© 2013, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Ping-Pin Zheng
AU  - Rob Willemsen
AU  - Johan M Kros
PY  - 2013/08
DA  - 2013/08
TI  - A Powerful Approach of Live Digital Data Communication in Biomedical Research and Teaching:Detection of Various Impaired Vascular Perfusion in Zebrafish Knockdown Models by Video Imaging
BT  - Proceedings of the 2013 International Conference on Advanced ICT and Education
PB  - Atlantis Press
SP  - 853
EP  - 855
SN  - 1951-6851
UR  - https://doi.org/10.2991/icaicte.2013.173
DO  - 10.2991/icaicte.2013.173
ID  - Zheng2013/08
ER  -