XinPing Liu, JiuXiang Yuan, RongQing Hu, JianHuang Zou, FengMei Yang, LiHua Yao
To investigate the blocking effects of classical swine fever (CSF) spleen vaccine on vertical transmission of classical swine fever virus (CSFV) and porcine reproductive and respiratory syndrome virus (PRRSV) co-infection in sows. Sows infected CSFV+PRRSV were selected from three large-scale pig farms and they were randomly divided into group I and group II. The sows in the group I were set as experimental group and vaccinated with CSF spleen vaccine at a 2 times normal dose per pig; and sows in group II were set as control group and vaccinated with CSF cell vaccine at a 6 times normal dose per pig. The antigens of piglets were detected by enzyme-linked immunosorbent assay (ELISA) method. Our results revealed that the blocking rate on the antigen of piglets in the experimental group (79.25%, 42/53) was significantly higher than that in the control group (50.94%, 27/53) (p<0.01). Collectively, these results demonstrate that CSF spleen vaccine has a good blocking effects on vertical transmission of CSFV+PPRSV co-infection in sows.