Proceedings of the 12th International Conference on Green Technology (ICGT 2022)

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Optimization of Centella asiatica (L.) Urban Dosage in Improving Memory of Mice with Brain Necrosis Model

Authors
Bayyinatul Muchtaromah1, *, Ely Nuril Fajriyah1, Wahyuni Risalatul Azmah1, Maharani Retna Duhita1, Arif Nur Muhammad Ansori2, 3, Tanjina Sharmin4
1Master Program of Biology, Faculty of Science and Technology, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Malang, Indonesia
2Professor Nidom Foundation, Surabaya, Indonesia
3Doctoral Program of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia
4Faculty of Chemical Engineering, Fukuoka Univeristy, Fukuoka, Japan
*Corresponding author. Email: bayyinatul@bio.uin-malang.ac.id
Corresponding Author
Bayyinatul Muchtaromah
Available Online 29 May 2023.
DOI
10.2991/978-94-6463-148-7_44How to use a DOI?
Keywords
Brain necrosis; Centella asiatica (L.) Urban extract (EkCa); Memory; Streptozotocin
Abstract

Brain necrosis in mice can be triggered by injection of streptozotocin (STZ), causing nerve cell injury that can trigger neurodegenerative diseases. Centella asiatica (L.) Urban is one of the herbs whose triterpenoid compounds have neuroregenerative activity, so it is widely used as Centella asiatica (L.) Urban extract (EkCa). The aim of this study was to determine the optimization of EkCa dose in improving memory of mice in brain necrosis model. The design of this study was completely randomized design with 36 male Balb/C strain mice weighing 25–30 g with 6 treatments (control, EkCa 20, 30, 40 mg/kgBW, and metformin 25 mg) with each treatment repeated 6 times. Brain necrosis mice were made by injecting multiple doses of STZ intraperitoneally at a dose of 40 mg/kgBW for 3 days and 60 mg/kgBW for 2 consecutive days. Memory was obtained from the calculation of retention time (RT-LT > 0). Data analysis used One Way Anova test followed with Duncan test. The results showed that the optimum dose was 30 mg/kgBW (P < 0.05). From the results of the study, it can be concluded that EkCa has neuroregenerative activity so that it can improve the memory of mice with brain necrosis model.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 12th International Conference on Green Technology (ICGT 2022)
Series
Advances in Engineering Research
Publication Date
29 May 2023
ISBN
10.2991/978-94-6463-148-7_44
ISSN
2352-5401
DOI
10.2991/978-94-6463-148-7_44How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Bayyinatul Muchtaromah
AU  - Ely Nuril Fajriyah
AU  - Wahyuni Risalatul Azmah
AU  - Maharani Retna Duhita
AU  - Arif Nur Muhammad Ansori
AU  - Tanjina Sharmin
PY  - 2023
DA  - 2023/05/29
TI  - Optimization of Centella asiatica (L.) Urban Dosage in Improving Memory of Mice with Brain Necrosis Model
BT  - Proceedings of the 12th International Conference on Green Technology (ICGT 2022)
PB  - Atlantis Press
SP  - 443
EP  - 451
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-148-7_44
DO  - 10.2991/978-94-6463-148-7_44
ID  - Muchtaromah2023
ER  -