Cross-linking Peptide Vaccine Heat Shock Protein 72 and Alpha-fetoprotein Elicited Specific Dendritic Cells, Cytotoxic T-lymphocyte Cells and Natural Killing Cells

DOI

10.2991/icmsa-15.2015.8How to use a DOI?

Keywords

Alpha-fetoprotein (AFP), Heat Shock Protein 72 (HSP72), Cytotoxicity, Hepatocellular carcinoma (HCC).

Abstract

Alpha-fetoprotein (AFP) is an oncofetal protein during Hepatocellular carcinoma (HCC) development which could generate weaker and less reproducible antitumor protection, and may serve as a target for immunotherapy. Therefore, it is imperative to enhance its immunogenicity and develop therapeutic vaccines to eliminate AFP-expressing tumors. In this study, by way of peptide synthesis method, we constructed a potential therapeutic peptide vaccine, heat shock protein 72 (HSP72) and AFP peptide containing the specific antigen epitope. Our results demonstrated that AFP peptide and HSP72 synergistically exhibited significant increases in AFP-specific dendritic cells, CD8+ T cells, natural killing cells responses and impressive antitumor effects against AFP-expressing tumors. Our study suggests that a tumor peptide vaccine by cross-linking AFP peptide and HSP72 peptide is a promising approach for HCC therapy.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiao-Ping Wang
AU  - Bing Xu
AU  - Huan-Ping Lin
AU  - Qian Zhao
AU  - Ke-Pei Zhang
AU  - Yi-Xin Yang
PY  - 2014/06
DA  - 2014/06
TI  - Cross-linking Peptide Vaccine Heat Shock Protein 72 and Alpha-fetoprotein Elicited Specific Dendritic Cells, Cytotoxic T-lymphocyte Cells and Natural Killing Cells
BT  - Proceedings of the 2015 International Conference on Material Science and Applications
PB  - Atlantis Press
SP  - 42
EP  - 46
SN  - 2352-541X
UR  - https://doi.org/10.2991/icmsa-15.2015.8
DO  - 10.2991/icmsa-15.2015.8
ID  - Wang2014/06
ER  -