Determination of Mesalazine Using Terbium Rare Earth Ions as a Fluorescence Probe
- 10.2991/icmsa-15.2015.10How to use a DOI?
- Ulcerative Colitis, Mesalazine, Terbium Rare Earth, Fluorescent, Content Determination.
Ulcerative colitis is chronic nonspecific colitis. Now,the main first-line drugs are preparations with mesalazine. Chemical name of mesalazine is 5- aminosalicylic acid (5-ASA), which one of colon target drugs has function of anti-inflammatory by inhibit process of leukotriene, prostaglandin E(PG) and free radical. Comparing with traditional SASP drugs used for treating colitis, 5-ASA has character of less harmful to body. In recent decade, mechanism and preparation of the mesalazine have attended at home and abroad. This paper established the rare earth fluorescence probe, which a new kind of technology for drug determination, contenting 5-ASA. It is more convenient, shortcut, accuracy than common methods of titration, ultraviolet spectrophotometry and high-performance liquid chromatography. According this, it provided a new and viable method of determination of 5-ASA. This method also can assist to research 5-ASA in the subjects that biopharmaceutical analysis, pharmacokinetics and clinical pharmacy, required strict experiment conditions.
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Yu-Guang Lv AU - Di Song AU - Du A AU - Ji-Hui Zheng AU - Hong-Bing Gao AU - Xiao-Li Qi AU - Jiang Wu AU - Zhong-Ping Gong AU - Jie Teng PY - 2014/06 DA - 2014/06 TI - Determination of Mesalazine Using Terbium Rare Earth Ions as a Fluorescence Probe BT - Proceedings of the 2015 International Conference on Material Science and Applications PB - Atlantis Press SP - 51 EP - 56 SN - 2352-541X UR - https://doi.org/10.2991/icmsa-15.2015.10 DO - 10.2991/icmsa-15.2015.10 ID - Lv2014/06 ER -