Study on Histocompatibility and Biodegradability of Polylactic Acid Gel in Rats

DOI

10.2991/icmsa-15.2015.109How to use a DOI?

Keywords

Polylactic Acid Gel, histocompatibility, Biodegradability, Postoperative Adhesions.

Abstract

Objective: To investigatethe effects on histocompatibility and biodegradability of bioabsorbablepolylacticacid (PLA) gelin rats. Methods: Longitudinal incision of 30 mm was made along the spine, and subcutaneous tissues were separated bluntly to make four subcutaneous pouches, and PLA gel of different molecular weight (5, 10 and 20 kD) was implanted into the pouches. 4, 7, 11 and 14 weeks after implantation, the samples and surrounding tissues were collected to perform HE staining; meanwhile, the samples were weighted and compared after drying. Results: There were few inflammatory cells accumulations in tissues treated with different molecular weight PLA gel. The degradation rate of 5 kD-PLA gel was faster than other groups. With increase of the molecular weight of PLA gel, the degradation rate was gradually decreased. Conclusion: Our findings indicated that PLA gel had good biocompatibility and a definite degrading effect, which could be further used in surgery.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ting Wang
AU  - Pei-Ling Cai
AU  - Xin Heng
AU  - Li-Jia Cheng
PY  - 2014/06
DA  - 2014/06
TI  - Study on Histocompatibility and Biodegradability of Polylactic Acid Gel in Rats
BT  - Proceedings of the 2015 International Conference on Material Science and Applications
PB  - Atlantis Press
SP  - 597
EP  - 600
SN  - 2352-541X
UR  - https://doi.org/10.2991/icmsa-15.2015.109
DO  - 10.2991/icmsa-15.2015.109
ID  - Wang2014/06
ER  -