Study on Histocompatibility and Biodegradability of Polylactic Acid Gel in Rats
Ting Wang, Pei-Ling Cai, Xin Heng, Li-Jia Cheng
Available Online June 2014.
- https://doi.org/10.2991/icmsa-15.2015.109How to use a DOI?
- Polylactic Acid Gel, histocompatibility, Biodegradability, Postoperative Adhesions.
- Objective: To investigatethe effects on histocompatibility and biodegradability of bioabsorbablepolylacticacid (PLA) gelin rats. Methods: Longitudinal incision of 30 mm was made along the spine, and subcutaneous tissues were separated bluntly to make four subcutaneous pouches, and PLA gel of different molecular weight (5, 10 and 20 kD) was implanted into the pouches. 4, 7, 11 and 14 weeks after implantation, the samples and surrounding tissues were collected to perform HE staining; meanwhile, the samples were weighted and compared after drying. Results: There were few inflammatory cells accumulations in tissues treated with different molecular weight PLA gel. The degradation rate of 5 kD-PLA gel was faster than other groups. With increase of the molecular weight of PLA gel, the degradation rate was gradually decreased. Conclusion: Our findings indicated that PLA gel had good biocompatibility and a definite degrading effect, which could be further used in surgery.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Ting Wang AU - Pei-Ling Cai AU - Xin Heng AU - Li-Jia Cheng PY - 2014/06 DA - 2014/06 TI - Study on Histocompatibility and Biodegradability of Polylactic Acid Gel in Rats BT - 2015 International Conference on Material Science and Applications (icmsa-15) PB - Atlantis Press SP - 597 EP - 600 SN - 2352-541X UR - https://doi.org/10.2991/icmsa-15.2015.109 DO - https://doi.org/10.2991/icmsa-15.2015.109 ID - Wang2014/06 ER -