Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)

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Neutrophil to Lymphocyte Ratio and Hs-CRP Predict Mortality in COVID-19 Patients

Authors
Evi Nurhayatun, Nurhasan Agung Prabowo, Dhani Redhono Harioputro, Wachid Putranto, Dono Indarto, Bambang Purwanto
Corresponding Author
Evi Nurhayatun
Available Online 16 January 2021.
DOI
10.2991/ahsr.k.210115.016How to use a DOI?
Keywords
Neutrophil-to-Lymphocyte Ratio, Hs-CRP, mortality, COVID-19
Abstract

Background: Inflammation plays an important role in the pathogenesis of COVID-19 and can be an important factor in the prognosis. The innate immune response to a respiratory infection is characterised by an influx of neutrophils to the lungs, particularly the alveoli. A sustained release of anti-inflammatory cytokines may lead to widespread apoptosis of lymphocytes, resulting in lymphopenia. Hs-CRP is an indicator of COVID-19 inflammation. The aim of this study was to analyse Neutrophil-to-Lymphocyte Ratio (NLR) and Hs-CRP in order to predict mortality in COVID-19 patients. Research methods: This research was conducted at Moewardi Hospital in July 2020. The subjects were COVID-19 patients. NLR is neutrophils divided by lymphocytes using a haematology analyser. The examination of Hs-CRP was conducted utilizing the ELISA method. Statistical test with an independent T-test and cox proportional hazard analysis with p <0.05 was also used. Results: The results showed that Hs-CRP and NLR increased in COVID-19 patients who later died and obtained lower levels of surviving (p = 0.001 and p = 0.11). Hs-CRP increased the risk of death for COVID-19 patients (p = 0.18; HR = 1.036) and NLR also increased the risk of death for COVID-19 patients (p = 0.08; HR = 1.34) Conclusion: Neutrophil-to-Lymphocyte Ratio and Hs-CRP predicted mortality in COVID-19 patients

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
Series
Advances in Health Sciences Research
Publication Date
16 January 2021
ISBN
10.2991/ahsr.k.210115.016
ISSN
2468-5739
DOI
10.2991/ahsr.k.210115.016How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Evi Nurhayatun
AU  - Nurhasan Agung Prabowo
AU  - Dhani Redhono Harioputro
AU  - Wachid Putranto
AU  - Dono Indarto
AU  - Bambang Purwanto
PY  - 2021
DA  - 2021/01/16
TI  - Neutrophil to Lymphocyte Ratio and Hs-CRP Predict Mortality in COVID-19 Patients
BT  - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
PB  - Atlantis Press
SP  - 80
EP  - 82
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210115.016
DO  - 10.2991/ahsr.k.210115.016
ID  - Nurhayatun2021
ER  -