Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)

Correlation Between Renal Activity Index and C3 Complement Expression in Mouse Lupus Nephritis Model

Authors
Nurhasan Agung Prabowo, Arief Nurudhin, Salma Asri Novia
Corresponding Author
Nurhasan Agung Prabowo
Available Online 16 January 2021.
DOI
https://doi.org/10.2991/ahsr.k.210115.015How to use a DOI?
Keywords
Renal Activity of Lupus, C3 Complement, Lupus Nephritis Model
Abstract

Background: Lupus nephritis is a disease which currently has no definitive therapy. For lupus nephritis, histological examination remains the best option to assess the degree of disease activity, which is essential for therapy evaluation and monitoring. At present, there is no single laboratory that can be used to assess disease activity. Therefore, this study aims to determine the correlation between renal activity index and C3 complement expression in mouse lupus nephritis model. Research methods: The study was conducted on male mice. Lupus was induced using intraperitoneal pristane injection at 0.5 cc, then left for four months. At the end of the 4th month, the mice were sacrificed, and histological examination of mice’s kidneys and renal C3 complement expressions were evaluated. Statistical tests were done using t-test, Mann-Whitney test, and Spearman correlation test, with a significance level of P <0.05. Results: activity index on histological examination of mouse kidney in such aspects as glomerular proliferation, karyorrhexis, and fibrinoid necrosis, cellular crescents, hyaline deposits, and interstitial inflammation were associated with C3 complement expression in kidney tissue (r = 0.680; p = 0.001) Conclusion: The study demonstrateds that the activity index in kidney histological examination correlates with C3 complement expressions in the lupus nephritis model.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
Series
Advances in Health Sciences Research
Publication Date
16 January 2021
ISBN
978-94-6239-315-8
ISSN
2468-5739
DOI
https://doi.org/10.2991/ahsr.k.210115.015How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Nurhasan Agung Prabowo
AU  - Arief Nurudhin
AU  - Salma Asri Novia
PY  - 2021
DA  - 2021/01/16
TI  - Correlation Between Renal Activity Index and C3 Complement Expression in Mouse Lupus Nephritis Model
BT  - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
PB  - Atlantis Press
SP  - 75
EP  - 79
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210115.015
DO  - https://doi.org/10.2991/ahsr.k.210115.015
ID  - Prabowo2021
ER  -