Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)

Effect of High-Fat Diet on Systolic Blood Pressure in STZ-Induced Diabetic Adolescent Sprague Dawley Rats

Authors
Dini Islamiana, Intan Susmita Rafsanjani, Miranti Dewi Pramaningtyas, Ana Fauziyati
Corresponding Author
Miranti Dewi Pramaningtyas
Available Online 16 January 2021.
DOI
https://doi.org/10.2991/ahsr.k.210115.014How to use a DOI?
Keywords
Diabetes mellitus, systolic blood pressure, obesity, youth
Abstract

Hypertension and diabetes mellitus are two major contributing factors in cardiovascular disease development. Previous studies have shown that insulin resistance is worse in obese youth than adults. This research compared the effect of diabetes mellitus and high fat diet on systolic blood pressure between the normal, streptozotocin (STZ)-induced only and STZ with high fat diet-induced (HFD) of adolescent rats. The subjects were adolescent male Sprague- Dawley rats aged 3 weeks divided into 3 groups. The STZ-induced group received 35 mg / kg STZ by intraperitoneal injection while the STZ and HFD-induced group received the STZ after 14 days high fat diet treatment. The blood glucose was measured after fasting of 12 hours, 3 days after STZ induction using the glucosimeter. The systolic blood pressure was measured in all groups before the research and 3 days after STZ induction. There was a significant difference in rat systolic blood pressure before the intervention. All groups experienced an increase in systolic blood pressure. Systolic blood pressure increase about 3.00 mmHg (2.14%), 1.83 mmHg (1.45%), and 39.33 mmHg (36.87%) respectively for normal, STZ-induced, and STZ and HFD-induced groups. The increase of systolic blood pressure can occur massively in the STZ-induced diabetic adolescent rats with HFD-induced obesity.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
Series
Advances in Health Sciences Research
Publication Date
16 January 2021
ISBN
978-94-6239-315-8
ISSN
2468-5739
DOI
https://doi.org/10.2991/ahsr.k.210115.014How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Dini Islamiana
AU  - Intan Susmita Rafsanjani
AU  - Miranti Dewi Pramaningtyas
AU  - Ana Fauziyati
PY  - 2021
DA  - 2021/01/16
TI  - Effect of High-Fat Diet on Systolic Blood Pressure in STZ-Induced Diabetic Adolescent Sprague Dawley Rats
BT  - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
PB  - Atlantis Press
SP  - 69
EP  - 74
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210115.014
DO  - https://doi.org/10.2991/ahsr.k.210115.014
ID  - Islamiana2021
ER  -