Effect of High-Fat Diet on Systolic Blood Pressure in STZ-Induced Diabetic Adolescent Sprague Dawley Rats
- https://doi.org/10.2991/ahsr.k.210115.014How to use a DOI?
- Diabetes mellitus, systolic blood pressure, obesity, youth
Hypertension and diabetes mellitus are two major contributing factors in cardiovascular disease development. Previous studies have shown that insulin resistance is worse in obese youth than adults. This research compared the effect of diabetes mellitus and high fat diet on systolic blood pressure between the normal, streptozotocin (STZ)-induced only and STZ with high fat diet-induced (HFD) of adolescent rats. The subjects were adolescent male Sprague- Dawley rats aged 3 weeks divided into 3 groups. The STZ-induced group received 35 mg / kg STZ by intraperitoneal injection while the STZ and HFD-induced group received the STZ after 14 days high fat diet treatment. The blood glucose was measured after fasting of 12 hours, 3 days after STZ induction using the glucosimeter. The systolic blood pressure was measured in all groups before the research and 3 days after STZ induction. There was a significant difference in rat systolic blood pressure before the intervention. All groups experienced an increase in systolic blood pressure. Systolic blood pressure increase about 3.00 mmHg (2.14%), 1.83 mmHg (1.45%), and 39.33 mmHg (36.87%) respectively for normal, STZ-induced, and STZ and HFD-induced groups. The increase of systolic blood pressure can occur massively in the STZ-induced diabetic adolescent rats with HFD-induced obesity.
- © 2021, the Authors. Published by Atlantis Press.
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- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Dini Islamiana AU - Intan Susmita Rafsanjani AU - Miranti Dewi Pramaningtyas AU - Ana Fauziyati PY - 2021 DA - 2021/01/16 TI - Effect of High-Fat Diet on Systolic Blood Pressure in STZ-Induced Diabetic Adolescent Sprague Dawley Rats BT - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020) PB - Atlantis Press SP - 69 EP - 74 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.210115.014 DO - https://doi.org/10.2991/ahsr.k.210115.014 ID - Islamiana2021 ER -