Neurodegeneration and Huntington’s disease

DOI

10.2991/assehr.k.220110.141How to use a DOI?

Keywords

Huntington’s disease; neurodegenerative disorder; treatment; chromosome; newborn cells

Abstract

Neurodegeneration is related to many kinds of age-related neuron diseases. Taking Huntington’s disease(HD) as an example, it is a fatal hereditary neurodegenerative disorder caused by expanded CAG repeats in specific genes. There is no fundamental treatment for HD, and the mechanism of its occurrence and development is unclear. Currently, there are only drugs that improve individual symptoms, and lose effectiveness after a certain period of time due to resistance. In order to better understand the pathogenesis of this kind of disease and explore more feasible treatment methods, the author briefly reviews the research of basic pathology of this kind of disease, and selecting HD to discuss deeply for its possible treatment means. The result shows that the gene-related brain structural changes is closely related to the occurrence of disease, and it is a genetic disease. Since disease treatments and drugs must be screened and validated in animal models, it is very important to establish cell and animal models that can accurately simulate disease phenotypes and pathology to develop effective disease treatments.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Yintao Kang
PY  - 2022
DA  - 2022/01/28
TI  - Neurodegeneration and Huntington’s disease
BT  - Proceedings of the 2021 International Conference on Public Art and Human Development ( ICPAHD 2021)
PB  - Atlantis Press
SP  - 736
EP  - 739
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220110.141
DO  - 10.2991/assehr.k.220110.141
ID  - Kang2022
ER  -