Inhibition Against Xanthine Oxidase Enzyme by Andrographis paniculata, Orthosiphon aristatus, and Salacca zalacca Fruit Water and Ethanolic Extracts as Antigout
- DOI
- 10.2991/assehr.k.210909.099How to use a DOI?
- Keywords
- andrographis paniculata, antigout, inhibitor, Orthosiphon aristatus, Salacca zalacca, xanthine oxidase
- Abstract
Gout is a joint disease caused by the accumulation of uric salt crystals that causes an acute inflammatory response, or the accumulation of these in soft tissue (cartilage). Cat’s whiskers leaves (Orthosiphon aristatus), bitter herbs (Andrographis paniculata), and snake fruit (Salacca zalacca) are native Indonesian plants that are commonly used to reduce uric acid levels in the body. This study tested the bioactive potency and the xanthine oxidase enzyme inhibition in vitro of water and ethanol extracts from these three plants to evaluate their potency as antigout. The phytochemical assay result of each extract shows the presence of flavonoid and tannin. Probit analysis results of water and ethanol extracts show a lethal concentration value of 50 (LC50) below 1000 μg/mL, and the smallest LC50 value produced by cat’s whiskers water extract is 366.34 μg/mL. The inhibitory activity of xanthine oxidase enzyme by cat whiskers leaves water extract is shown by the smallest IC50 value of 84.78 μg/mL, which proves that cat’s whiskers leave water extract has the potency as herbal ingredient for alternative uric acid treatments.
- Copyright
- © 2021, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Trivadila AU - Ade Laskar Julian AU - Sekar Ilma Tiarani AU - Siti Sa’diah AU - Dyah Iswantini PY - 2021 DA - 2021/09/11 TI - Inhibition Against Xanthine Oxidase Enzyme by Andrographis paniculata, Orthosiphon aristatus, and Salacca zalacca Fruit Water and Ethanolic Extracts as Antigout BT - Proceedings of the 2nd International Conference on Science, Technology, and Modern Society (ICSTMS 2020) PB - Atlantis Press SP - 462 EP - 469 SN - 2352-5398 UR - https://doi.org/10.2991/assehr.k.210909.099 DO - 10.2991/assehr.k.210909.099 ID - 2021 ER -