Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

Aging Process Immunity and Its Relation with Periodontal Disease in Genetic Aspect

Authors
Pitu Wulandari, Elza Ibrahim Auerkari
Corresponding Author
Pitu Wulandari
Available Online February 2018.
DOI
https://doi.org/10.2991/idcsu-17.2018.58How to use a DOI?
Keywords
Aging, immune, genetic, periodontal
Abstract
One of the factors that related to biological aging in humans is genetic. The aging process can occur due to genetic accumulation and epigenetic modification that lead to progressive cellular damage and weakened tissue functions that causing limitation of abilities to maintain the balance/ homeostasis. Increased vulnerability to a number of inflammations due to the aging process is closely related to rising in prevalence and severity of periodontitis. The purpose of this paper is to analyze immunity of the aging process and its relation to periodontal disease in genetic aspect. Biological aging is affected by genetic variation that changes several genes that causing changes of several cell functions. Changes in DNA methylation are one of the mechanisms that contribute to the aging process, including the body immune system. Aging process influences both adaptive and innate body immune system. Changes in an immune and genetic system in the aging process could increase the severity of periodontal disease. As a conclusion, periodontal disease is an inflammation that related to aging. In the aging process, there are changes in the immune system that causes elder people more susceptible to periodontal infection. In addition, genetic and epigenetic factors also play a role in periodontal changes in elderly.
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Proceedings
International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)
Part of series
Advances in Health Sciences Research
Publication Date
February 2018
ISBN
978-94-6252-474-3
ISSN
2468-5739
DOI
https://doi.org/10.2991/idcsu-17.2018.58How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Pitu Wulandari
AU  - Elza Ibrahim Auerkari
PY  - 2018/02
DA  - 2018/02
TI  - Aging Process Immunity and Its Relation with Periodontal Disease in Genetic Aspect
BT  - International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idcsu-17.2018.58
DO  - https://doi.org/10.2991/idcsu-17.2018.58
ID  - Wulandari2018/02
ER  -