Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)

The Genetics of Asthma

Authors
Astrinia Ristia Putri, Elza Ibrahim Auerkari
Corresponding Author
Astrinia Ristia Putri
Available Online May 2018.
DOI
https://doi.org/10.2991/idsm-17.2018.5How to use a DOI?
Keywords
asthma, genetics, epigenetics
Abstract
Asthma is a chronic inflammatory disease characterized by airway obstruction and hyper-responsiveness. It is a complex disorder influenced by genetic and en-vironmental factors, which contribute to the clinical manifestations of asthma. Asthma may affect the lower respiratory tract, causing epithelial damage, mucus hyper-secretion, edema, bronchospasm, and airway remodeling. Genetic studies have uncovered single nucleotide polymorphisms (SNPs) associated with asthma. However, knowledge of the functional impact of these SNPs is lacking. Several genes associated with asthma have been well characterized on a functional level: ORMDL3, S1PR1, PHF11, F3, and ADAM33. Epigenetic modifications, which in-clude DNA methylation, histone modification, and miRNA, affect transcriptional activity in multiple genetic pathways associated with the development of asthma. The aim of this paper is to describe the pathophysiology, etiology, genetics, and epigenetics of asthma and the factors contributing to its development.
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Proceedings
11th International Dentistry Scientific Meeting (IDSM 2017)
Part of series
Advances in Health Sciences Research
Publication Date
May 2018
ISBN
978-94-6252-513-9
ISSN
2468-5739
DOI
https://doi.org/10.2991/idsm-17.2018.5How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Astrinia Ristia Putri
AU  - Elza Ibrahim Auerkari
PY  - 2018/05
DA  - 2018/05
TI  - The Genetics of Asthma
BT  - 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.5
DO  - https://doi.org/10.2991/idsm-17.2018.5
ID  - Putri2018/05
ER  -