The Genetics of Asthma
Astrinia Ristia Putri, Elza Ibrahim Auerkari
Astrinia Ristia Putri
Available Online May 2018.
- https://doi.org/10.2991/idsm-17.2018.5How to use a DOI?
- asthma, genetics, epigenetics
- Asthma is a chronic inflammatory disease characterized by airway obstruction and hyper-responsiveness. It is a complex disorder influenced by genetic and en-vironmental factors, which contribute to the clinical manifestations of asthma. Asthma may affect the lower respiratory tract, causing epithelial damage, mucus hyper-secretion, edema, bronchospasm, and airway remodeling. Genetic studies have uncovered single nucleotide polymorphisms (SNPs) associated with asthma. However, knowledge of the functional impact of these SNPs is lacking. Several genes associated with asthma have been well characterized on a functional level: ORMDL3, S1PR1, PHF11, F3, and ADAM33. Epigenetic modifications, which in-clude DNA methylation, histone modification, and miRNA, affect transcriptional activity in multiple genetic pathways associated with the development of asthma. The aim of this paper is to describe the pathophysiology, etiology, genetics, and epigenetics of asthma and the factors contributing to its development.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Astrinia Ristia Putri AU - Elza Ibrahim Auerkari PY - 2018/05 DA - 2018/05 TI - The Genetics of Asthma BT - 11th International Dentistry Scientific Meeting (IDSM 2017) PB - Atlantis Press SP - 35 EP - 44 SN - 2468-5739 UR - https://doi.org/10.2991/idsm-17.2018.5 DO - https://doi.org/10.2991/idsm-17.2018.5 ID - Putri2018/05 ER -