Effect of GHR variation on mandibular height
- Arief Johanes Halim, Elza Ibrahim Auerkari
- Corresponding Author
- Arief Johanes Halim
Available Online May 2018.
- https://doi.org/10.2991/idsm-17.2018.4How to use a DOI?
- growth hormone receptor, mandibular height, orthopedic reactions, advance of treatment
- Growth hormone (GH) is a hormone produced by the acidophil of the anterior pi-tuitary gland that affects the growth and development of craniofacial structures. GH must bind to the growth hormone receptor (GHR) to stimulate the target site. As GH is the primary regulator of bone growth, the GHR plays an important role in determining morphological traits. The GHR is also found in the condyle region. Few studies have examined the correlation between variation in the GHR and mandibular height in Korean, Japanese, and Han Chinese populations. These studies showed that amino acid substitutions at P561T, C422F, and 1526L were correlated with mandibular height. Various environmental factors contribute to mandibular morphogenesis, but we know that genetic factors also play a consid-erable role. Previous studies revealed correlations between genetic variants of GHR and mandibular morphogenesis. Knowledge of the genetic markers involved in craniofacial morphogenesis will allow clinicians to more easily predict orthope-dic reactions in advance of treatment.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Arief Johanes Halim AU - Elza Ibrahim Auerkari PY - 2018/05 DA - 2018/05 TI - Effect of GHR variation on mandibular height BT - 11th International Dentistry Scientific Meeting (IDSM 2017) PB - Atlantis Press SN - 2468-5739 UR - https://doi.org/10.2991/idsm-17.2018.4 DO - https://doi.org/10.2991/idsm-17.2018.4 ID - Halim2018/05 ER -