Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)

Molecular Genetics and Epigenetics of Ankyloglossia

Authors
Lili Nur Indah Sari, Elza Ibrahim Auerkari
Corresponding Author
Lili Nur Indah Sari
Available Online May 2018.
DOI
https://doi.org/10.2991/idsm-17.2018.14How to use a DOI?
Keywords
Ankyloglossia, Tongue tie, Genetics, Epigenetics, Lingual frenulum
Abstract
Ankyloglossia is an autosomal dominant condition with in complete penetrence, haracterized by frenulum lingual hypertrophy that produces a thicker and shorter tongue, which may cause significant problems with breastfeeding. It also causes speech and oral motor problems. The prevalence of ankyloglossia is approxi-mately 4% in babies, and tongue tie is estimated to affect 489,343 newborns, rep-resenting 10% of the Indonesian newborn population of 4,893,435.1 For reasons unknown, this condition is seen more often in males than in females. Ankylo-glossia may be isolated or accompanied by cleft palate (CPX). The presentation of this condition is associated with nucleotide base substitution mutations in the TBX22 gene and the G-protein-coupled receptor Lgr5 and can be related to epi-genetic modification, including DNA methylation and SUMOylation, which is one kind of histone modification.
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Proceedings
11th International Dentistry Scientific Meeting (IDSM 2017)
Part of series
Advances in Health Sciences Research
Publication Date
May 2018
ISBN
978-94-6252-513-9
ISSN
2468-5739
DOI
https://doi.org/10.2991/idsm-17.2018.14How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Lili Nur Indah Sari
AU  - Elza Ibrahim Auerkari
PY  - 2018/05
DA  - 2018/05
TI  - Molecular Genetics and Epigenetics of Ankyloglossia
BT  - 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.14
DO  - https://doi.org/10.2991/idsm-17.2018.14
ID  - Sari2018/05
ER  -