Molecular Genetics and Epigenetics of Ankyloglossia
Lili Nur Indah Sari, Elza Ibrahim Auerkari
Lili Nur Indah Sari
Available Online May 2018.
- https://doi.org/10.2991/idsm-17.2018.14How to use a DOI?
- Ankyloglossia, Tongue tie, Genetics, Epigenetics, Lingual frenulum
- Ankyloglossia is an autosomal dominant condition with in complete penetrence, haracterized by frenulum lingual hypertrophy that produces a thicker and shorter tongue, which may cause significant problems with breastfeeding. It also causes speech and oral motor problems. The prevalence of ankyloglossia is approxi-mately 4% in babies, and tongue tie is estimated to affect 489,343 newborns, rep-resenting 10% of the Indonesian newborn population of 4,893,435.1 For reasons unknown, this condition is seen more often in males than in females. Ankylo-glossia may be isolated or accompanied by cleft palate (CPX). The presentation of this condition is associated with nucleotide base substitution mutations in the TBX22 gene and the G-protein-coupled receptor Lgr5 and can be related to epi-genetic modification, including DNA methylation and SUMOylation, which is one kind of histone modification.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Lili Nur Indah Sari AU - Elza Ibrahim Auerkari PY - 2018/05 DA - 2018/05 TI - Molecular Genetics and Epigenetics of Ankyloglossia BT - 11th International Dentistry Scientific Meeting (IDSM 2017) PB - Atlantis Press SP - 103 EP - 115 SN - 2468-5739 UR - https://doi.org/10.2991/idsm-17.2018.14 DO - https://doi.org/10.2991/idsm-17.2018.14 ID - Sari2018/05 ER -